Tetracycline-producing strains of Streptomyces aureofaciens expressed SauLPI restriction-modification (R-M) system, which recognized specific DNA sequence 5'-GCCGGC-3' (isoschizomer Nael). The activation of the second R-M system SauLPII (5'-GAGCTC-3', isoschizomer of XhoI), which was silent during the growth cycle, after a foreign DNA transfer into this strain was observed. This phenomenon was tentatively explained as a response of the cells against the exogenous DNA entering the cells. The involvement of a SOS-like response in induction of R-M system genes in S. aureofaciens strains has been considered.

• MeSH
• Bacteriophage mu genetics   MeSH
• DNA Replication MeSH
• Deoxyribonucleases, Type II Site-Specific metabolism   MeSH
• SOS Response, Genetics MeSH
• Streptomyces aureofaciens enzymology   genetics   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• CTCGAG-specific type II deoxyribonucleases MeSH Browser
• Deoxyribonucleases, Type II Site-Specific MeSH