Nejvíce citovaný článek - PubMed ID 12079858
The responses of serum and adipose Fatty acids to a one-year weight reduction regimen in female obese monozygotic twins
Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic acid as a possible marker of endogenous lipogenesis or its functions as a lipokine are under debate. Objective was to assess the predictive role of adipose triglycerides fatty acids in weight maintenance in participants of the DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects with > 8 % weight loss were randomized to 5 ad libitum weight maintenance diets for 6 months: low protein (P)/low glycemic index (GI) (LP/LGI), low P/high GI (LP/HGI), high P/low GI (HP/LGI), high P/high GI (HP/HGI), and a control diet. Fatty acid composition in adipose tissue triglycerides was determined by gas chromatography in 195 subjects before the LCD (baseline), after LCD and weight maintenance. Weight change after the maintenance phase was positively correlated with baseline adipose palmitoleic (16:1n-7), myristoleic (14:1n-5) and trans-palmitoleic acid (16:1n-7t). Negative correlation was found with baseline oleic acid (18:1n-9). Lower baseline monounsaturated fatty acids (14:1n-5, 16:1n-7 and trans 16:1n-7) in adipose tissue triglycerides predict better weight maintenance. Lower oleic acid predicts lower weight decrease. These findings suggest a specific role of monounsaturated fatty acids in weight management and as weight change predictors.
- MeSH
- dospělí MeSH
- glykemický index MeSH
- hmotnostní úbytek fyziologie MeSH
- kyselina olejová chemie metabolismus MeSH
- kyseliny mastné mononenasycené chemie metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mastné kyseliny chemie metabolismus MeSH
- tělesná hmotnost MeSH
- triglyceridy analýza metabolismus MeSH
- tuková tkáň chemie metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 9-tetradecenoic acid MeSH Prohlížeč
- kyselina olejová MeSH
- kyseliny mastné mononenasycené MeSH
- mastné kyseliny MeSH
- palmitoleic acid MeSH Prohlížeč
- triglyceridy MeSH