Nejvíce citovaný článek - PubMed ID 15178306
Synthesis and in vitro antifungal activity of 4-substituted phenylguanidinium salts
The influence of subinhibitory concentrations of six established and 19 newly synthesized antifungal compounds on the dimorphic transition of three C. albicans strains was evaluated in the filamentation-inducing medium. Amphotericin B was found to produce almost complete inhibition in the germination at a concentration of 1/10 of the corresponding MIC and partial inhibition at a concentration as low as MIC/50. Flucytosine and four azole derivatives were proven ineffective. From the newly synthesized drugs, the incrustoporin derivative LNO6-22, two phenylguanidine derivatives (PG15, PG45), and four thiosalicylanilide derivatives, in particular, showed results comparable to those of amphotericin B, with a high inhibition of germ tube formation at concentrations of MIC/10. In general, concentrations of MIC/50 had no visible effect.
- MeSH
- amfotericin B farmakologie MeSH
- antifungální látky chemická syntéza chemie farmakologie MeSH
- Candida albicans účinky léků růst a vývoj MeSH
- gama-butyrolakton analogy a deriváty chemická syntéza chemie farmakologie MeSH
- guanidiny chemická syntéza chemie farmakologie MeSH
- mikrobiální testy citlivosti metody normy MeSH
- morfogeneze účinky léků MeSH
- salicylany chemická syntéza chemie farmakologie MeSH
- sulfhydrylové sloučeniny chemická syntéza chemie farmakologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- amfotericin B MeSH
- antifungální látky MeSH
- gama-butyrolakton MeSH
- guanidiny MeSH
- incrustoporin MeSH Prohlížeč
- phenylguanidine MeSH Prohlížeč
- salicylany MeSH
- sulfhydrylové sloučeniny MeSH
- thiosalicylic acid MeSH Prohlížeč
