The influence of subinhibitory concentrations of six established and 19 newly synthesized antifungal compounds on the dimorphic transition of three C. albicans strains was evaluated in the filamentation-inducing medium. Amphotericin B was found to produce almost complete inhibition in the germination at a concentration of 1/10 of the corresponding MIC and partial inhibition at a concentration as low as MIC/50. Flucytosine and four azole derivatives were proven ineffective. From the newly synthesized drugs, the incrustoporin derivative LNO6-22, two phenylguanidine derivatives (PG15, PG45), and four thiosalicylanilide derivatives, in particular, showed results comparable to those of amphotericin B, with a high inhibition of germ tube formation at concentrations of MIC/10. In general, concentrations of MIC/50 had no visible effect.

• MeSH
• Amphotericin B pharmacology   MeSH
• Antifungal Agents chemical synthesis   chemistry   pharmacology   MeSH
• Candida albicans drug effects   growth & development   MeSH
• 4-Butyrolactone analogs & derivatives   chemical synthesis   chemistry   pharmacology   MeSH
• Guanidines chemical synthesis   chemistry   pharmacology   MeSH
• Microbial Sensitivity Tests methods   standards   MeSH
• Morphogenesis drug effects   MeSH
• Salicylates chemical synthesis   chemistry   pharmacology   MeSH
• Sulfhydryl Compounds chemical synthesis   chemistry   pharmacology   MeSH
• Dose-Response Relationship, Drug MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Amphotericin B MeSH
• Antifungal Agents MeSH
• 4-Butyrolactone MeSH
• Guanidines MeSH
• incrustoporin MeSH Browser
• phenylguanidine MeSH Browser
• Salicylates MeSH
• Sulfhydryl Compounds MeSH
• thiosalicylic acid MeSH Browser