INTRODUCTION: Liposuction is a surgical method for fat aspiration, which reduces the amount of subcutaneous fat. Adipose tissue is important in regulating insulin sensitivity; however excess tissue accumulation, especially in the form of intra-abdominal fat, is associated with an increased risk of developing metabolic syndrome. Clinical findings associated with metabolic syndrome include central obesity, dyslipidemia, insulin resistance, hypertension, and atherosclerotic disease. Nevertheless, the long-term metabolic impact of liposuction is unclear. We aimed to analyze the effects of liposuction on the lipid profile, arterial blood pressure, and glucose metabolism in healthy women. PATIENTS AND METHODS: Twelve patients who underwent liposuction were included in the study. The blood pressures, arterial blood pressure, and lipid profiles were measured before surgery and approximately 1 year after surgery. In addition, insulin sensitivities were measured using oral glucose tolerance test. RESULTS: In the long term, liposuction led to a slight reduction of body fat (p<0.05), but it did not affect the blood pressure or insulin sensitivity. Although the levels of total and low-density lipoprotein cholesterol were reduced, these decreases were not statistically significant. DISCUSSION: The results of the study are consistent with some of the published data, which indicated a slight decrease in blood lipids. CONCLUSION: Small-volume liposuction does not appear to induce significant metabolic changes. A larger cohort and longer follow-ups are needed to evaluate the effects on the lipid profile, blood pressure, and glucose metabolism of the patients being studied.

• Klíčová slova
• Hyperlipidemia, Hypertension, Insulin resistance, Liposuction, Metabolic syndrome,
• Publikační typ
• časopisecké články MeSH

OBJECTIVE: Childhood overweight and obesity has been a major global problem for a long time, with a steadily increasing prevalence of obesity and a growing number of cases of serious health complications associated with childhood obesity. The main objective of the study is to assess the prevalence of overweight and obesity in boys and girls before the COVID-19 pandemic in the Czech Republic. METHODS: Body height, weight, BMI, and body composition (fat free mass, skeletal muscle mass, body fat, visceral fat area) were assessed in a cohort of 4,475 subjects (2,180 boys and 2,295 girls) aged 6-15 years. Somatic status was assessed by standardized anthropometry and body composition was determined by bioelectrical impedance. The subjects were classified according to BMI in percentile bands (up to 3rd percentile, P3-10, P25-75, P75-90, P90-97, above 97th percentile). Statistical analysis was performed using the software TIBCO Statistica 14.0.015. RESULTS: During growth, statistical differences in the proportion of fat-free mass and fat fractions were found between boys and girls. In boys, there is an increase in muscle mass, in girls, there is an increase in the proportion of fat fraction. Sexual differentiation is pronounced during pubertal growth. By their BMI, 10.32% of the boys and 7.36% of the girls were categorized as overweight, and 8.12% of the boys and 7.71% of the girls were categorized as obese. Using bioelectrical impedance analysis and the percentage of fat fraction, 21.61% of the boys and 21.87% of the girls were categorized as obese; 5.96% of the boys and 8.19% of the girls were found to have visceral adipose tissue posing a health risk (more than 100 cm2). From 2002 to 2019, there was a significant increase of 3.72% in the overweight category for boys and 1.36% for girls, while the obesity category showed an increase of 3.62% for boys and 4.91% for girls. CONCLUSION: The results confirm the increasing negative trend of overweight and obesity in the BMI and the relative body fat categories in children aged 6-15 years. Greater attention and monitoring of the effectiveness of preventive measures is needed to slow and stop the obesity epidemic which has health, social and economic impacts on the entire society.

• Klíčová slova
• body composition, body fat, body mass index, children, visceral fat area,
• MeSH
• antropometrie MeSH
• COVID-19 * epidemiologie   MeSH
• dítě MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• mladiství MeSH
• nadváha * epidemiologie   MeSH
• obezita dětí a dospívajících * epidemiologie   MeSH
• pandemie MeSH
• prevalence MeSH
• SARS-CoV-2 MeSH
• složení těla MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH

BACKGROUND: Laparoscopic greater curvature plication (LGCP) is an innovative restrictive technique designed to reduce gastric volume by plication at the region of greater curvature. The long-term efficacy, safety, and the metabolic effects of this procedure are the subject of this study. METHODS: One hundred twenty-seven patients were enrolled; 84 underwent laparoscopic sleeve gastrectomy (LSG) and 43, LGCP. LSG and LGCP were then compared during long-term follow-ups in terms of glycemic control, hormone and lipid secretion, and changes in body composition. Measured parameters included serum glucose, triglycerides, high- and low-density lipoprotein cholesterol, testosterone, estradiol, leptin, adiponectin, ghrelin, fatmass, and lean body mass. RESULTS: Significant weight-loss and a reduced body composition resulted from either procedure vs. baseline (i.e., pre-surgery), with levels of fasting glucose and glycated hemoglobin also showing statistically significant reductions (at 3 and 18 months for either surgery). Intergroup comparisons for glycemic parameters yielded no statistically significant differences. However, a dramatic reduction in ghrelin was detected following LSG, falling from pre-surgery levels of 140.7 to 69.6 ng/L by 6 months (P < 0.001). Subsequently, ghrelin levels increased, reaching 107.8 ng/L by month 12. Conversely, after LGCP, a statistically significant increase in ghrelin was seen, rising from 130.0 ng/L before surgery to 169.0 ng/L by month 12, followed by a slow decline. CONCLUSIONS: Good metabolic outcomes were obtained following LGCP, which might be mediated via altered glucose metabolism and GI hormones. Nevertheless, this method is less effective than LSG, possibly due to its preservation of the entire stomach, including secretory regions.

• Klíčová slova
• Ghrelin, Hormonal changes, Laparoscopic greater curvature plication, Metabolic surgery, Sleeve gastrectomy,
• MeSH
• dospělí MeSH
• gastrektomie metody   rehabilitace   MeSH
• gastroplastika metody   rehabilitace   MeSH
• ghrelin metabolismus   MeSH
• glykovaný hemoglobin metabolismus   MeSH
• hmotnostní úbytek fyziologie   MeSH
• krevní glukóza metabolismus   MeSH
• laparoskopie metody   rehabilitace   MeSH
• lidé středního věku MeSH
• lidé MeSH
• metabolom * MeSH
• morbidní obezita metabolismus   chirurgie   MeSH
• následné studie MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• pozorovací studie MeSH
• Názvy látek
• ghrelin MeSH
• glykovaný hemoglobin MeSH
• krevní glukóza MeSH