To evaluate the sympathetic innervation of the female diabetic heart, resting heart rate and sympathetic tone were assessed in vivo, and effect of tyramine on spontaneous beating rate, norepinephrine atrial concentrations, uptake, and release were determined in vitro in streptozotocin- (STZ-) treated rats and respective controls aged 3 months to 2 years. Resting bradycardia, decreased sympathetic tone, deceleration of spontaneous beating rate, and slightly declining carrier-mediated, but preserved exocytotic norepinephrine release from the atria were found in younger diabetic rats while the reactivity of the right atria to tyramine was not affected with age and disease duration. Diabetic two-year-old animals displayed symptoms of partial spontaneous recovery including normoglycemia, increased plasma insulin concentrations, fully recovered sympathetic tone, but putative change, in releasable norepinephrine tissue stores. Our data suggested that female diabetic heart exposed to long-lasting diabetic conditions seems to be more resistant to alteration in sympathetic innervation than the male one.

• MeSH
• atropin farmakologie   MeSH
• časové faktory MeSH
• experimentální diabetes mellitus chemicky indukované   metabolismus   patofyziologie   MeSH
• inzulin metabolismus   MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• metipranolol farmakologie   MeSH
• pohlavní dimorfismus MeSH
• potkani Wistar MeSH
• srdce účinky léků   inervace   patofyziologie   MeSH
• srdeční frekvence účinky léků   fyziologie   MeSH
• streptozocin MeSH
• sympatický nervový systém účinky léků   patologie   patofyziologie   MeSH
• sympatolytika farmakologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• atropin MeSH
• inzulin MeSH
• metipranolol MeSH
• streptozocin MeSH
• sympatolytika MeSH