The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSP) as well as of succinate dehydrogenase (SDG), NADH dehydrogenase (NDG) and fumarate hydratase (FHT) were examined in relation to mitochondrial ultrastructure changes in Aspergillus niger exposed to N,N-bis(3-aminopropyl)dodecylamine (Apd) that was shown to exhibit fungicidal activity. There was a progressive increase in SOD, CAT and GSP activities 1 and 4 h after 0.05 and 0.1 % Apd application. However, this was followed by a pronounced activity decrease when 0.05 % Apd treatment was prolonged by 1 d. The destructive effect on fungal morphology was observed when this fungicidal agent was applied at the concentration of 0.1 % for 1 d. In the treated hyphae mitochondria degenerated after all organelles. The morphological malformations of mitochondria had an impact on their metabolic state; however, the activities of SDG, NDG and FHT were affected to a different extent. In A. niger the fungicidal effect of Apd could be mediated by oxidative stress impairing the vital mitochondria-related cellular functions.

• MeSH
• aminy farmakologie   MeSH
• antifungální látky farmakologie   MeSH
• Aspergillus niger účinky léků   metabolismus   ultrastruktura   MeSH
• časové faktory MeSH
• fumarasa metabolismus   MeSH
• glutathionperoxidasa metabolismus   MeSH
• hyfy účinky léků   ultrastruktura   MeSH
• inhibitory enzymů farmakologie   MeSH
• katalasa metabolismus   MeSH
• mitochondrie účinky léků   metabolismus   ultrastruktura   MeSH
• NADH-dehydrogenasa metabolismus   MeSH
• sukcinátdehydrogenasa metabolismus   MeSH
• superoxiddismutasa metabolismus   MeSH
• transmisní elektronová mikroskopie MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• aminy MeSH
• antifungální látky MeSH
• fumarasa MeSH
• glutathionperoxidasa MeSH
• inhibitory enzymů MeSH
• katalasa MeSH
• N,N-bis(3-aminopropyl)dodecylamine MeSH Prohlížeč
• NADH-dehydrogenasa MeSH
• sukcinátdehydrogenasa MeSH
• superoxiddismutasa MeSH