AIMS: The relationship of tumour volume, radiotherapy treatment time and other prognostic factors affecting prognosis was evaluated. METHODS: 184 patients with locally advanced head and neck cancer were treated with radical intensity modulated radiotherapy (IMRT) and compared retrospectively. RESULTS: In the multivariate analysis the overall survival was dependent on gross tumour volume (GTV), clinical stage (CS), radiotherapy treatment time (RTT) and p16 status. Local control was influenced by GTV, overall RTT and age. DFS was significantly affected by GTV, CS, RTT, p16 status and concomitant chemotherapy (CHT). CONCLUSIONS: The tumour volume and the radiotherapy treatment time were the most significant prognostic factors with the best outcomes in patients with GTV ≤ 55 cc and RTT ≤ 48 days (mean LC 8.1, DFS 7.1 and OS 6.4 years) and worst outcomes with GTV > 55 cc and RTT >48 days (mean LC 4.4, mean DFS 3.2 and mean OS 2.6 years).
- Klíčová slova
- IMRT, head and neck cancer, local control, radiotherapy treatment time, survival, tumour volume,
- MeSH
- celková dávka radioterapie MeSH
- lidé MeSH
- nádory hlavy a krku * radioterapie MeSH
- prognóza MeSH
- radioterapie s modulovanou intenzitou * MeSH
- retrospektivní studie MeSH
- tumor burden MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
