Nejvíce citovaný článek - PubMed ID 16963240
BACKGROUND: Several findings indicate that stress may influence epileptiform discharges manifesting in temporal-limbic areas, which may become a potential trigger of psychosis that may manifest without neurologically diagnosed epilepsy. Some findings suggest that measures assessing levels of inter-hemispheric information connection may reveal the spread of subclinical epileptiform neural activity associated with psychotic and seizure-like symptoms. Recent research also suggests that electrodermal activity (EDA), which is related to limbic activations, may allow indirect measurement of interhemispheric information transmission. These findings about the interhemispheric spread of information suggest a hypothesis that heightened spread of information between the brain hemispheres might indirectly indicate epileptiform discharges spreading between hemispheres. METHODS: We have analyzed and measured EDA and also cognitive and affective epileptic-like symptoms (CPSI, complex partial seizure-like symptoms), symptoms of chronic stress (Trauma Symptoms Checklist-40, TSC-40), and psychotic symptoms in 31 schizophrenia patients and compared these data with 31 healthy controls. RESULTS: The results indicate that in schizophrenia patients, the values of pointwise transinformation (PTI) calculated from right and left EDA time series are related to CPSI symptoms (Spearman correlation between CPSI and PTI is R = 0.48; p < 0.01) and symptoms of chronic stress (Spearman correlation between TSC-40 and PTI is R = 0.37, p < 0.05); both during mild stress conditions caused by conflicting (incongruent) Stroop task. CONCLUSION: The analysis indicates potentially diagnostically useful results suggesting that heightened PTI values may reflect autonomic activations that hypothetically might be linked to higher interhemispheric transmission related to spreading of epileptiform discharges between hemispheres.
- Klíčová slova
- electrodermal activity, epileptiform activity, schizophrenia, stress, temporal epileptic-like symptoms, transinformation,
- Publikační typ
- časopisecké články MeSH
BACKGROUND AND OBJECTIVES: Recent evidence indicates that cerebral palsy is connected to specific autonomic dysregulation between sympathetic and parasympathetic efferent pathways, likely linked to hemispheric influences. These findings suggest a hypothesis that contralateral interhemispheric disinhibition, which may occur on various levels of brain processing including motor functions, could be linked to specific functional dysregulation and structural lesions, which may play a specific role in the modulation of autonomic functions and lead to autonomic dysregulation in cerebral palsy. METHOD: With the aim of comparing autonomic functions as they relate to interhemispheric modulatory influences during therapeutically indicated stereotactic cerebellar stimulation, we have performed bilateral electrodermal activity measurement and calculations of pointwise transinformation (PTI) in a patient with cerebral palsy. Measurement was performed during therapeutic deep cerebellar stimulation in two cerebellar areas in anterior cerebellar lobe-culmen (left electrode) and central lobule-superior cerebellar peduncle (right electrode). RESULTS: The results indicate that information transference (PTI) is able to distinguish the states related to specific cerebellar stimulations and that lowest levels of the PTI have been found during stimulation of the central lobule-superior cerebellar peduncle (electrode deepest contact 1), indicating a significantly increased level of inhibition between the left and right sides. CONCLUSION: The results may present potentially useful clinical findings indicating that increased PTI calculated from electrodermal activity could indirectly indicate disinhibitory activity as a possible indicator of a failure of interhemispheric communication that could explain some specific pathogenetic mechanisms in cerebral palsy. Nevertheless, these results need detailed confirmation in further research, as well as reliable clinical evaluation of their usefulness in the therapy of cerebral palsy.
BACKGROUND: According to recent clinical findings epileptiform activity in temporolimbic structures may cause depressive and other psychiatric symptoms that may occur independently of any seizure in patient's history. In addition in these patients subclinical seizure-like activity with indirect clinical manifestations likely may occur in a form of various forms of cognitive, affective, memory, sensory, behavioral and somatic symptoms (the so-called complex partial seizure-like symptoms). A typical characteristic of epileptiform changes is increased neural synchrony related to spreading of epileptiform activity between hemispheres even in subclinical conditions i.e. without seizures. These findings suggest a hypothesis that measures reflecting a level of synchronization and information transfer between hemispheres could reflect spreading of epileptiform activity and might be related to complex partial seizure-like symptoms. METHODS AND FINDINGS: Suitable data for such analysis may provide various physiological signals reflecting brain laterality, as for example bilateral electrodermal activity (EDA) that is closely related to limbic modulation influences. With this purpose we have performed measurement and analysis of bilateral EDA and compared the results with psychometric measures of complex partial seizure-like symptoms, depression and actually experienced stress in 44 patients with unipolar depression and 35 healthy controls. The results in unipolar depressive patients show that during rest conditions the patients with higher level of complex partial seizure like symptoms (CPSI) display increased level of EDA transinformation (PTI) calculated between left and right EDA records (Spearman correlation between CPSI and PTI is r = 0.43, p = 0.004). CONCLUSIONS: The result may present potentially useful clinical finding suggesting that increased EDA transinformation (PTI) could indirectly indicate increased neural synchrony as a possible indicator of epileptiform activity in unipolar depressive patients treated by serotoninergic antidepresants.
- MeSH
- depresivní poruchy komplikace psychologie MeSH
- dospělí MeSH
- epilepsie komplikace psychologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- záchvaty psychologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Alcohol dependence during withdrawal and also in abstinent period in many cases is related to reduced inhibitory functions and kindling that may appear in the form of psychosensory symptoms similar to temporal lobe epilepsy frequently in conditions of normal EEG and without seizures. Because temporal lobe epileptic activity tend to spread between hemispheres, it is possible to suppose that measures reflecting interhemispheric information transfer such as electrodermal activity (EDA) might be related to the psychosensory symptoms. METHODS AND FINDINGS: We have performed measurement of bilateral EDA, psychosensory symptoms (LSCL-33) and alcohol craving (ACQ) in 34 alcohol dependent patients and 32 healthy controls. The results in alcohol dependent patients show that during rest conditions the psychosensory symptoms (LSCL-33) are related to EDA transinformation (PTI) between left and right EDA records (Spearman r = 0.44, p<0.01). CONCLUSIONS: The result may present potentially useful clinical finding suggesting a possibility to indirectly assess epileptiform changes in alcohol dependent patients.
- MeSH
- alkoholismus komplikace MeSH
- dospělí MeSH
- epilepsie komplikace diagnóza MeSH
- galvanická kožní odpověď MeSH
- lidé středního věku MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
