A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and tested in human breast cancer MDA-MB-231 cells. Zinc and copper complexes, but not nickel complex, were found to be more active against cellular 26S proteasome than against purified 20S proteasome core particle. One of the possible explanations is inhibition of JAMM domain in the 19S proteasome lid.

• MeSH
• Ditiocarb analogs & derivatives   chemistry   pharmacology   MeSH
• Enzyme Inhibitors chemistry   pharmacology   MeSH
• Proteasome Inhibitors * MeSH
• Humans MeSH
• Copper MeSH
• Molecular Structure MeSH
• Cell Line, Tumor MeSH
• Breast Neoplasms enzymology   pathology   MeSH
• Nickel MeSH
• Organometallic Compounds chemistry   pharmacology   MeSH
• Proteasome Endopeptidase Complex metabolism   MeSH
• Zinc MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Research Support, N.I.H., Extramural MeSH
• Research Support, U.S. Gov't, Non-P.H.S. MeSH
• Names of Substances
• bis(N,N-diethyldithiocarbamate)Cu (II) complex MeSH Browser
• Ditiocarb MeSH
• Enzyme Inhibitors MeSH
• Proteasome Inhibitors * MeSH
• Copper MeSH
• Nickel MeSH
• Organometallic Compounds MeSH
• Proteasome Endopeptidase Complex MeSH
• Zinc MeSH