BACKGROUND Abnormal metabolism of fatty acids (FA) is considered to play a role in human cancers, including esophageal cancer (EC). Nevertheless, there have been only a few studies dealing with the influence of the chemotherapy or radiotherapy on the plasma FA profiles. In this work we compared FA in plasma phosphatidylcholine (PC) of the patients with squamous EC and healthy subjects and investigated changes in the FA spectrum during neoadjuvant chemoradiotherapy (CRT). MATERIAL AND METHODS Forty-two men with squamous EC were compared with age-matched healthy controls. The EC group was subjected to concurrent neoadjuvant CRT. We analyzed FA in plasma PC before and after CRT. RESULTS The EC group was characterized by increased levels of both saturated and monounsaturated FA, associated with an increased index of SCD1 (stearoyl-CoA desaturase-1). Moreover, decreased levels of linoleic acid and total polyunsaturated FA (PUFA) n-6 were found in EC patients. The CRT was accompanied by increased docosahexaenoic acid and total PUFA n-3 content in plasma PC, concurrently with the decrease of estimated activity of SCD1. CONCLUSIONS We found that patients with EC had altered FA profile in plasma PC, which could be related to abnormal FA metabolism in cancer (e.g., altered synthesis de novo, b-oxidation, desaturation, and elongation). The described changes in FA profiles during CRT could be involved in favorable functioning of CRT. Further studies investigating the plasma FA compositions and their changes due to CRT in EC patients are warranted.

• MeSH
• Chemoradiotherapy MeSH
• Adult MeSH
• Phosphatidylcholines blood   MeSH
• Fatty Acids, Monounsaturated blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Fatty Acids blood   MeSH
• Lipid Metabolism physiology   MeSH
• Esophageal Neoplasms blood   drug therapy   radiotherapy   therapy   MeSH
• Neoadjuvant Therapy MeSH
• Esophageal Squamous Cell Carcinoma MeSH
• Carcinoma, Squamous Cell blood   drug therapy   radiotherapy   therapy   MeSH
• Stearoyl-CoA Desaturase metabolism   MeSH
• Case-Control Studies MeSH
• Treatment Outcome MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Phosphatidylcholines MeSH
• Fatty Acids, Monounsaturated MeSH
• Fatty Acids MeSH
• Stearoyl-CoA Desaturase MeSH

BACKGROUND: The convergence of nutritional, genetic, and inflammatory factors plays a significant role in the pathophysiology of squamous cell esophageal cancer (SCEC). The parameters of inflammation, indices of nutritional status, and adipocyte-derived hormones such as leptin, adiponectin, and resistin have been shown to be prognostic factors in some gastrointestinal and pancreatic cancers. MATERIAL/METHODS: Forty-two patients with SCEC were subjected to a multimodal regimen of concurrent neoadjuvant chemoradiotherapy (CRT) followed by surgery. We retrospectively analyzed the impact of pretreatment values of serum leptin, adiponectin, resistin, soluble leptin receptor, C-reactive protein, TNF alpha, leukocytes, and indices of nutritional status (BMI, plasma total protein, albumin, cholesterol, and triacylglycerols) on overall survival (OS). RESULTS: Univariate analysis revealed significant a negative correlation between OS and serum adiponectin (p=0.027), and a positive relationship was found between serum albumin (p=0.002), cholesterol (p=0.049) level, and OS. In multivariate analysis, only the trend (p=0.086) for negative serum adiponectin association with the OS was observed. CONCLUSIONS: In men with SCEC treated by neoadjuvant concurrent CRT and esophagectomy, high pretreatment level of serum adiponectin was associated with shorter OS while the serum albumin and cholesterol were associated with longer OS.

• MeSH
• Adiponectin blood   MeSH
• Survival Analysis MeSH
• Chemoradiotherapy * MeSH
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Multivariate Analysis MeSH
• Esophageal Neoplasms blood   surgery   therapy   MeSH
• Pilot Projects MeSH
• Preoperative Care * MeSH
• Proportional Hazards Models MeSH
• Aged MeSH
• Esophageal Squamous Cell Carcinoma MeSH
• Carcinoma, Squamous Cell blood   surgery   therapy   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Adiponectin MeSH