The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18). Next, cortisol levels were higher in IE patients than in those with BM and CAP, and at one time point, cortisol was also higher in patients with gram-negative sepsis when compared to those with gram-positive infections. Furthermore, cortisol and MCP-1 levels correlated positively with the daily measured SOFA score. In addition, HBP levels were significantly higher in patients with IE than in those with BM. Our findings suggest that MCP-1, sCD14, IL-6, IL-10, cortisol, and HBP are modulated by the source of sepsis and that elevated MCP-1 and cortisol plasma levels are associated with sepsis-induced organ dysfunction.

• MeSH
• Biomarkers metabolism   MeSH
• Chemokine CCL2 metabolism   MeSH
• Chemokine CCL4 metabolism   MeSH
• Hydrocortisone metabolism   MeSH
• Interleukin-10 metabolism   MeSH
• Interleukin-6 metabolism   MeSH
• Interleukin-8 metabolism   MeSH
• Antimicrobial Cationic Peptides metabolism   MeSH
• Blood Proteins metabolism   MeSH
• Middle Aged MeSH
• Humans MeSH
• Lipopolysaccharide Receptors metabolism   MeSH
• Critical Care MeSH
• Aged MeSH
• Sepsis metabolism   MeSH
• Carrier Proteins metabolism   MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• AZU1 protein, human MeSH Browser
• Biomarkers MeSH
• Chemokine CCL2 MeSH
• Chemokine CCL4 MeSH
• Hydrocortisone MeSH
• Interleukin-10 MeSH
• Interleukin-6 MeSH
• Interleukin-8 MeSH
• Antimicrobial Cationic Peptides MeSH
• Blood Proteins MeSH
• Lipopolysaccharide Receptors MeSH
• Carrier Proteins MeSH