Two novel thiosemicarbazones and eight novel 2-{[1-(5-alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones were prepared and tested against a panel of eight fungal strains-Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/I, Trichosporon asahii 1188, Aspergillus fumigatus 231, Lichtheimia corymbifera 272, and Trichophyton interdigitale 445. 1,3-Thiazolidin-4-ones exhibited activity against all strains, the most potent derivative was 2-{[1-(5-butylpyrazin-2-yl)ethylidene]hydrazono}e-1,3-thiazolidin-4-one. Susceptibility of C. glabrata to the studied 1,3-thiazolidin-4-ones (minimum inhibitory concentrations (MICs) were in the range 0.57 to 2.78 mg/L) is of great interest as this opportunistic pathogen is poorly susceptible to azoles and becomes resistant to echinocandins. Antifungal potency of thiosemicarbazones was slightly lower than that of 1,3-thiazolidin-4-ones.

• Keywords
• 1,3-thiazolidin-4-ones, Candida glabrata, acetylpyrazine, antifungal, thiosemicarbazones,
• MeSH
• Antifungal Agents chemical synthesis   chemistry   pharmacology   MeSH
• Aspergillus drug effects   MeSH
• Candida drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Molecular Structure MeSH
• Mucorales drug effects   MeSH
• Thiazolidinediones chemical synthesis   chemistry   pharmacology   MeSH
• Thiosemicarbazones chemical synthesis   chemistry   pharmacology   MeSH
• Trichophyton drug effects   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Antifungal Agents MeSH
• Thiazolidinediones MeSH
• Thiosemicarbazones MeSH