The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age. Our results suggest that large, low-diversity public clones are created during pre-natal life, and survive over long periods, providing the basis of the public repertoire.

• MeSH
• antigenní specifita receptorů T-buněk genetika   MeSH
• dvojčata monozygotní genetika   MeSH
• genetická variace genetika   MeSH
• genová přestavba T-lymfocytů genetika   MeSH
• kultivované buňky MeSH
• lidé MeSH
• molekulární sekvence - údaje MeSH
• receptory antigenů T-buněk fyziologie   MeSH
• rekombinace genetická MeSH
• sekvence nukleotidů MeSH
• stárnutí genetika   imunologie   MeSH
• vývojová regulace genové exprese genetika   imunologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• receptory antigenů T-buněk MeSH