Most cited article - PubMed ID 26362893
Increased albumin quotient (QAlb) in patients after first clinical event suggestive of multiple sclerosis is associated with development of brain atrophy and greater disability 48 months later
The purpose of this work was to investigate the associations of serum cholesterol and apolipoproteins with measures of blood-brain barrier (BBB) permeability and CNS inflammation following the first clinical demyelinating event. This study included 154 patients [67% female; age, 29.5 ± 8.2 years (mean ± SD)] enrolled in a multi-center study of interferon β1-a treatment following the first demyelinating event. Blood and cerebrospinal fluid (CSF) were obtained at screening prior to treatment. A comprehensive serum lipid profile and multiple surrogate markers of BBB breakdown and CNS immune activity were obtained. Higher levels of serum HDL cholesterol (HDL-C) and ApoA-I were associated with lower CSF total protein level, CSF albumin level, albumin quotient, and CSF IgG level (all P ≤ 0.001 for HDL-C and all P < 0.01 for ApoA-I). HDL-C was also associated with CSF CD80+ (P < 0.001) and with CSF CD80+CD19+ (P = 0.007) cell frequencies. Higher serum HDL is associated with lower levels of BBB injury and decreased CD80+ and CD80+CD19+ cell extravasation into the CSF. HDL may potentially inhibit the initiation and/or maintenance of pathogenic BBB injury following the first demyelinating event.
- Keywords
- apolipoproteins, cholesterol, clinically isolated syndrome, high density lipoprotein,
- MeSH
- Apolipoproteins blood cerebrospinal fluid MeSH
- Biomarkers blood cerebrospinal fluid MeSH
- Demyelinating Diseases MeSH
- Adult MeSH
- Cholesterol, HDL blood MeSH
- Blood-Brain Barrier drug effects metabolism pathology MeSH
- Interferon-beta therapeutic use MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Nervous System Diseases blood cerebrospinal fluid MeSH
- Multiple Sclerosis blood cerebrospinal fluid drug therapy pathology MeSH
- Inflammation blood cerebrospinal fluid MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Apolipoproteins MeSH
- Biomarkers MeSH
- Cholesterol, HDL MeSH
- Interferon-beta MeSH
