Glyphosate (N-(phosphonomethyl)glycine) is an active substance of many herbicides. According to literature studies, glyphosate residues and their metabolites have been commonly detected in surface waters and toxicological reports confirmed negative effects on living organisms. In this study, the acute embryo toxicity of glyphosate into two different fish species-common carp (Cyprinus carpio) and zebrafish (Danio rerio)-was investigated. Lethal endpoints, development disorder, and, in addition, other sublethal endpoints such as hatching rate, formation of somites, and development of eyes, spontaneous movement, heartbeat/blood circulation, pigmentation, and edema were recorded to indicate the mode of action of the toxic compound. Hatching retardation (p < 0.05) was observed in experimental groups of common carp exposed to glyphosate with significant statistical difference especially at the highest concentration after 72, 96, and 120 hpf. The significantly highest cumulative mortality at concentration of 50 mg/l was observed. In contrast, hatching stimulation was observed in embryos of zebrafish exposed to the highest concentration of glyphosate. The significantly highest cumulative mortality for zebrafish was observed only at concentration of 50 mg/l. Based on our results, early life stages of common carp are more sensitive in comparison to zebrafish to the toxic action of glyphosate.

• Keywords
• Embryo toxicity tests, Fish, Glyphosate, Hatching, Herbicide, Malformation, Mortality,
• MeSH
• Water Pollutants, Chemical toxicity   MeSH
• Zebrafish growth & development   MeSH
• Species Specificity MeSH
• Embryo, Nonmammalian drug effects   MeSH
• Embryonic Development drug effects   MeSH
• Glycine analogs & derivatives   toxicity   MeSH
• Glyphosate MeSH
• Herbicides toxicity   MeSH
• Carps growth & development   MeSH
• Dose-Response Relationship, Drug MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Water Pollutants, Chemical MeSH
• Glycine MeSH
• Herbicides MeSH