INTRODUCTION: Papillary thyroid carcinoma (PTC) frequently harbors the BRAF V600E mutation. Recent research suggests that aggressive behavior in BRAF V600E+ PTC may be due to an undetected mutation in the TERT gene. This study aims to observe the clinicopathological features of BRAF V600+ PTC and correlate them with surgical treatment complications. METHODS: A retrospective analysis was conducted on the BRAF V600E+ PTC cohort from July 2019 to January 2023. The histopathological features and surgical treatment (total thyroidectomy - group A, total thyroidectomy + central block neck dissection - group B) complications were correlated. Patients with TERT and TP53 mutation were excluded. Next-generation sequencing and real-time PCR were used for genetic analysis. RESULTS: Out of 121 PTCs, 65 cases showed BRAF V600E mutation with the following features: intracapsular spread (13.8%), extracapsular spread (27.7%), extrathyroidal spread (15.4%), multifocality (26.2%), angioinvasion (12.3%), and local metastasis (27.7%). The incidence of surgical complications in group A/B was: reversible recurrent laryngeal nerve (RLN) paresis 3.7/7.1%, RLN paresis permanent 0/2.4%, paresthesia 6.8/23.8%, hypocalcemia 36.4/61.9% on day 1 and 27.3/33.3% on day 3, and bleeding 2.3/9.5%. There was no significant difference in clinicopathological features between the BRAF V600E+ and BRAF V600E- PTC groups. Group B had a significantly higher incidence of hypoacalcaemia on postoperative day 1 (p = 0.047). CONCLUSION: The BRAF V600E mutation will certainly remain important in the preoperative diagnosis of PTC. The more radical surgical procedures currently recommended may be abandoned in the future, particularly elective CLND, which has a higher risk of postoperative complications.

• Klíčová slova
• BRAF V600E, Cancer, Clinicopathologic features, Complications, Mutation, Papillary Thyroid Carcinoma (PTC), Surgery, TERT, Thyroid,
• MeSH
• dospělí MeSH
• krční disekce MeSH
• lidé středního věku MeSH
• lidé MeSH
• mutace * MeSH
• nádorový supresorový protein p53 * genetika   MeSH
• nádory štítné žlázy * genetika   chirurgie   patologie   MeSH
• papilární karcinom štítné žlázy * genetika   chirurgie   patologie   MeSH
• pooperační komplikace * etiologie   MeSH
• protoonkogenní proteiny B-Raf * genetika   MeSH
• retrospektivní studie MeSH
• senioři MeSH
• telomerasa * genetika   MeSH
• tyreoidektomie škodlivé účinky   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• BRAF protein, human MeSH Prohlížeč
• nádorový supresorový protein p53 * MeSH
• protoonkogenní proteiny B-Raf * MeSH
• telomerasa * MeSH
• TERT protein, human MeSH Prohlížeč
• TP53 protein, human MeSH Prohlížeč