Nejvíce citovaný článek - PubMed ID 38166151
Low genetic diversity of Treponema pallidum ssp. pertenue (TPE) isolated from patients' ulcers in Namatanai District of Papua New Guinea: Local human population is infected by three TPE genotypes
Haemophilus ducreyi (HD) is an important cause of cutaneous ulcers in several endemic regions, including the Western Pacific Region, especially among children. An HD sequence typing on swab samples taken from 1,081 ulcers in the Namatanai district of Papua New Guinea, during the pilot study for treatment of yaws, has been performed using the Grant typing system. Of the 363 samples that tested positive for the 16S rDNA of HD, the dsrA sequences of 270 samples were determined. Altogether they revealed 8 HD strain types circulating in Namatanai, including seven strain types of Class I (I.3, I.4, I.5, I.9, I.10, I.11, I.12) and one strain of Class II (II.3); four Class I types (I.9, I.10, I.11, I.12) were novel. The southern region of Namatanai (Matalai Rural) was identified as the region with the lowest genotype diversity and with most infections caused by HD Class II. The middle and northern subdistricts were affected mainly by HD Class I. Analysis of patient characteristics revealed that Class II HD infections were more often represented by longer-lasting ulcers than Class I HD infections. An increase in the prevalence of the I.10 strain was found after azithromycin administration compared to the untreated population at baseline likely reflecting higher infectivity of HD Class I, and more specifically strain type I.10.
- MeSH
- antibakteriální látky * terapeutické užití farmakologie MeSH
- azithromycin * terapeutické užití MeSH
- dítě MeSH
- DNA bakterií genetika MeSH
- dospělí MeSH
- frambézie mikrobiologie epidemiologie farmakoterapie MeSH
- fylogeneze MeSH
- genotyp * MeSH
- Haemophilus ducreyi * genetika izolace a purifikace účinky léků MeSH
- lidé středního věku MeSH
- lidé MeSH
- měkký vřed * mikrobiologie epidemiologie farmakoterapie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- pilotní projekty MeSH
- předškolní dítě MeSH
- RNA ribozomální 16S genetika MeSH
- sekvenční analýza DNA MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Papua Nová Guinea epidemiologie MeSH
- Názvy látek
- antibakteriální látky * MeSH
- azithromycin * MeSH
- DNA bakterií MeSH
- RNA ribozomální 16S MeSH
