The protective effect of pig immune colostrum, serum and immunoglobulins IgG, IgM and IgA against the enterotoxic strain of Escherichia coli O55, was studied in newborn germfree piglets. This strain produced accumulation of fluid and dilatation of intestine when injected into the ligated ileal segment of germfree piglets, which is considered to be the typical effect of enterotoxins. Erosion of the intestinal epithelium and penetration of bacteria into the submucosa were also observed. Immune serum, colostrum and all the immunoglobulin classes used produced a local protective effect, IgA being most effective. The mechanism of protection conferred by these immunoglobulins is discussed with respect to the possible pathogenic action of enterotoxic Escherichia coli O55 in the intestinal tract of immunologically virgin germfree piglets.

• MeSH
• antisérum * MeSH
• enterotoxiny biosyntéza   toxicita   MeSH
• Escherichia coli metabolismus   MeSH
• gnotobiologické modely MeSH
• ileum imunologie   MeSH
• imunita MeSH
• imunoglobulin A MeSH
• imunoglobulin G MeSH
• imunoglobulin M MeSH
• imunoglobuliny * MeSH
• infekce vyvolané Escherichia coli etiologie   imunologie   prevence a kontrola   MeSH
• kolostrum imunologie   MeSH
• novorozená zvířata MeSH
• pasivní imunizace MeSH
• prasata MeSH
• průjem etiologie   imunologie   prevence a kontrola   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antisérum * MeSH
• enterotoxiny MeSH
• imunoglobulin A MeSH
• imunoglobulin G MeSH
• imunoglobulin M MeSH
• imunoglobuliny * MeSH