The role played by lymphocytes in the pyretic response to scarlet fever toxin (ET) was studied in vivo using antilymphocyte serum (ALS). Two i.v. injections of ALS inhibited the pyretic response to a subsequent ET injection in rabbits. The course of endotoxin fever remained uninfluenced by ALS. Antipolymorphonuclear serum had no effect on the pyretic response to either of the toxins. Pretreatment with ALS also inhibited the skin reaction after i.d. injection of ET. These findings are further evidence a mediating role of lymphocytes in the biological effects of ET, among other things in the release of endogenous pyrogen.

• MeSH
• Antilymphocyte Serum pharmacology   MeSH
• Immune Sera pharmacology   MeSH
• Bacterial Toxins pharmacology   MeSH
• Endotoxins pharmacology   MeSH
• Exotoxins pharmacology   MeSH
• Fever chemically induced   MeSH
• Skin Tests MeSH
• Rabbits MeSH
• Leukocytes drug effects   MeSH
• Neutrophils immunology   MeSH
• Leukocyte Count MeSH
• Pyrogens * MeSH
• Salmonella paratyphi B MeSH
• Scarlet Fever microbiology   MeSH
• Streptococcus pyogenes analysis   MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Antilymphocyte Serum MeSH
• Immune Sera MeSH
• Bacterial Toxins MeSH
• Endotoxins MeSH
• Exotoxins MeSH
• Pyrogens * MeSH

• MeSH
• Cyclic AMP metabolism   MeSH
• Antilymphocyte Serum MeSH
• DNA biosynthesis   MeSH
• Endotoxins pharmacology   MeSH
• Freund's Adjuvant pharmacology   MeSH
• Macrophage Migration-Inhibitory Factors biosynthesis   MeSH
• Concanavalin A pharmacology   MeSH
• Rabbits MeSH
• Lectins pharmacology   MeSH
• Lymphocytes metabolism   MeSH
• Mitosis drug effects   MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Cyclic AMP MeSH
• Antilymphocyte Serum MeSH
• DNA MeSH
• Endotoxins MeSH
• Freund's Adjuvant MeSH
• Macrophage Migration-Inhibitory Factors MeSH
• Concanavalin A MeSH
• Lectins MeSH

• MeSH
• Toxins, Biological * administration & dosage   MeSH
• Chinchilla MeSH
• Immune Tolerance MeSH
• Cortisone therapeutic use   MeSH
• Leukocytes * MeSH
• Leukopenia chemically induced   MeSH
• Scarlet Fever immunology   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Toxins, Biological * MeSH
• Cortisone MeSH

• MeSH
• Toxins, Biological toxicity   MeSH
• Endotoxins toxicity   MeSH
• Fever chemically induced   MeSH
• Hydrocortisone pharmacology   MeSH
• Cortisone pharmacology   MeSH
• Skin Manifestations * MeSH
• Rabbits MeSH
• Salmonella typhi MeSH
• Scarlet Fever MeSH
• Streptococcus MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Toxins, Biological MeSH
• Endotoxins MeSH
• Hydrocortisone MeSH
• Cortisone MeSH