The extracellular level of brefeldin A fluctuates with the length of malonate inhibition. Following treatment with malonate, mycelial multiplication as opposed to brefeldin A formation, was preferentially increased in the maleate, fumarate, succinate, citrate, methyl palmitate and glucose replacement cultures. Competitive maleate--malonate, fumarate--malonate, succinate--malonate and citrate--malonate-inhibited replacement cultures gave significantly higher mycelial and brefeldin A yields than the sole malonate-inhibited replacement cultures.

• MeSH
• Anti-Bacterial Agents biosynthesis   MeSH
• Brefeldin A MeSH
• Cyclopentanes biosynthesis   MeSH
• Carboxylic Acids metabolism   MeSH
• Malonates pharmacology   MeSH
• Mitosporic Fungi drug effects   growth & development   metabolism   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Brefeldin A MeSH
• Cyclopentanes MeSH
• Carboxylic Acids MeSH
• Malonates MeSH