Spontaneous variants of the beromycin-producing strain Streptomyces glomeratus 3980 were divided into five groups (A-E) according to increasing antibiotic activity. The most active variants (group E) differed from the other types and the wild strain by a suppressed ability to produce aerial mycelium and melanoid piogment and by an increased production of propionic acid. Strains with a 12-fold higher antibiotic production capacity (with respect to strain 3980) were obtained by selection of superior segregants from submerged cultures of the E type.

• MeSH
• Anthracyclines MeSH
• Pigments, Biological biosynthesis   MeSH
• Genetic Variation MeSH
• Naphthacenes biosynthesis   MeSH
• Propionates biosynthesis   MeSH
• Antibiotics, Antineoplastic biosynthesis   MeSH
• Streptomyces cytology   genetics   metabolism   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anthracyclines MeSH
• beromycin, anthracycline MeSH Browser
• Pigments, Biological MeSH
• Naphthacenes MeSH
• Propionates MeSH
• Antibiotics, Antineoplastic MeSH