The immunostimulatory and immunoinhibitory effects of 44 hydroxyanthra- and hydroxynaphthoquinone derivatives in tissue culture were investigated. In the test system used, the final effect, i.e. production of antibodies against sheep red blood cells is a result of cooperation between macrophages, T lymphocytes and B lymphocytes. It was found when testing selected 20 derivatives that methylation, acetylation or substitution of the hydroxy group by the amino group led to the loss of the inhibitory activity and, on the contrary, pronounced immunostimulatory effects could be observed in other derivatives. Naphthoquinones (juglone, lawsone) were more effective as immunoinhibitors than anthraquinones (alizarin, quinizarin) and their derivatives. In both groups of compounds glucosidation results in a substantial increase of the immunoinhibitory effect. The present work is a part of a more extensive study concerning modification of the molecules of various compounds and its relationship with the effect on immunological reactions.

• MeSH
• adjuvancia imunologická farmakologie   MeSH
• anthrachinony farmakologie   MeSH
• buňky produkující protilátky účinky léků   MeSH
• erytrocyty imunologie   MeSH
• imunosupresiva farmakologie   MeSH
• kultivované buňky MeSH
• naftochinony farmakologie   MeSH
• ovce MeSH
• počet buněk MeSH
• slezina cytologie   imunologie   MeSH
• tvorba protilátek účinky léků   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• adjuvancia imunologická MeSH
• anthrachinony MeSH
• imunosupresiva MeSH
• naftochinony MeSH

A total of 40 substances were tested for their inhibitory effect on the multiplication of a bacteriophage in a growing culture of Bacillus licheniformis and their influence on bacitracin production. Acriflavine was the only substance which, at a concentration of 3 microgram ml-1, completely suppressed phage multiplication while having no effect on the growth of Bacillus licheniformis and on the production of the antibiotic.

• MeSH
• akriflavin farmakologie   MeSH
• antibakteriální látky MeSH
• antiinfekční látky farmakologie   MeSH
• Bacillus metabolismus   MeSH
• bacitracin biosyntéza   MeSH
• bakteriofágy účinky léků   růst a vývoj   MeSH
• replikace viru účinky léků   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• akriflavin MeSH
• antibakteriální látky MeSH
• antiinfekční látky MeSH
• bacitracin MeSH