The relationship was studied between the energy metabolism of the actinomycete Streptomyces aureofaciens and the biosynthesis of chlorotetracycline by this organism. The energy charge values in a culture of low-production strain were almost identical with those of a production variant but the total sum of adenylates was about 10 times higher. In the stationary growth phase both strains evinced a drop in energy charge values followed by a rise to the original level. An increase in the concentration of inorganic phosphate in fermentation medium caused a suppression of antibiotic formation in the lowproduction strain and further rise in the total adenylate level. The expression of the energy charge in Streptomyces aureofaciens acquires a complex character owing to the participation, apart from the adenylate system, of high-molecular polyphosphates as energy donors and the probable lack of a regulating mechanism such as the adenylate kinase reaction.

• MeSH
• adeninnukleotidy metabolismus   MeSH
• adenosindifosfát metabolismus   MeSH
• adenosinmonofosfát metabolismus   MeSH
• adenosintrifosfát metabolismus   MeSH
• chlortetracyklin biosyntéza   MeSH
• energetický metabolismus MeSH
• fosfáty metabolismus   MeSH
• genetická variace MeSH
• Streptomyces aureofaciens metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• adeninnukleotidy MeSH
• adenosindifosfát MeSH
• adenosinmonofosfát MeSH
• adenosintrifosfát MeSH
• chlortetracyklin MeSH
• fosfáty MeSH