The relationship was studied between the energy metabolism of the actinomycete Streptomyces aureofaciens and the biosynthesis of chlorotetracycline by this organism. The energy charge values in a culture of low-production strain were almost identical with those of a production variant but the total sum of adenylates was about 10 times higher. In the stationary growth phase both strains evinced a drop in energy charge values followed by a rise to the original level. An increase in the concentration of inorganic phosphate in fermentation medium caused a suppression of antibiotic formation in the lowproduction strain and further rise in the total adenylate level. The expression of the energy charge in Streptomyces aureofaciens acquires a complex character owing to the participation, apart from the adenylate system, of high-molecular polyphosphates as energy donors and the probable lack of a regulating mechanism such as the adenylate kinase reaction.

• MeSH
• Adenine Nucleotides metabolism   MeSH
• Adenosine Diphosphate metabolism   MeSH
• Adenosine Monophosphate metabolism   MeSH
• Adenosine Triphosphate metabolism   MeSH
• Chlortetracycline biosynthesis   MeSH
• Energy Metabolism MeSH
• Phosphates metabolism   MeSH
• Genetic Variation MeSH
• Streptomyces aureofaciens metabolism   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Adenine Nucleotides MeSH
• Adenosine Diphosphate MeSH
• Adenosine Monophosphate MeSH
• Adenosine Triphosphate MeSH
• Chlortetracycline MeSH
• Phosphates MeSH