Unlike the bovine pancreatic ribonuclease (RNAase A), bovine seminal ribonuclease (BS RNAase) displays various biological activities including antitumor cytotoxicity. To learn more about its antitumor activity, we investigated BS RNAase effect on athymic nude mice bearing various tumors. BS RNAase (250 micrograms per mouse per day) was administered to the mice with prostate carcinoma for three weeks by three different routes (intraperitoneally--i.p., subcutaneously--s.c., and intratumorally-i.t.). Administration i.p. was ineffective, while s.c. administration reduced significantly size of tumors and i.t. administration abolished half of the tumors in treated mice. The i.t. administration of BS RNase to nude mice bearing melanoma showed even better results. Eighty % of mice were without tumors and in the other mice the tumors were significantly diminished. The best antitumor effect was obtained in case of seminoma. All mice bearing this tumor were cured after ten doses of BS RNAase.
- MeSH
- endoribonukleasy aplikace a dávkování terapeutické užití MeSH
- experimentální nádory farmakoterapie MeSH
- melanom farmakoterapie MeSH
- myši nahé MeSH
- myši MeSH
- nádory prostaty farmakoterapie MeSH
- protinádorové látky aplikace a dávkování terapeutické užití MeSH
- screeningové testy protinádorových léčiv MeSH
- seminom farmakoterapie MeSH
- skot MeSH
- transplantace heterologní MeSH
- transplantace nádorů MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- skot MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- endoribonukleasy MeSH
- protinádorové látky MeSH
- ribonuclease SPL MeSH Prohlížeč
