• MeSH
• General Surgery history   MeSH
• History, 20th Century MeSH
• Check Tag
• History, 20th Century MeSH
• Publication type
• Biography MeSH
• Journal Article MeSH
• Historical Article MeSH
• Geographicals
• Czechoslovakia MeSH

• About
• Stanĕk, A

• MeSH
• History, 20th Century MeSH
• History of Pharmacy MeSH
• Check Tag
• History, 20th Century MeSH
• Publication type
• Biography MeSH
• Journal Article MeSH
• Historical Article MeSH
• Geographicals
• Czechoslovakia MeSH

• About
• Stanĕk, J

• MeSH
• Anatomy history   MeSH
• History, 19th Century MeSH
• Check Tag
• History, 19th Century MeSH
• Publication type
• Biography MeSH
• Journal Article MeSH
• Historical Article MeSH
• Geographicals
• Czechoslovakia MeSH

• About
• Stanĕk, V

• MeSH
• History, 19th Century MeSH
• History, 20th Century MeSH
• Check Tag
• History, 19th Century MeSH
• History, 20th Century MeSH
• Publication type
• Biography MeSH
• Journal Article MeSH
• Historical Article MeSH
• Geographicals
• Czechoslovakia MeSH

• About
• Stanĕk, V

• MeSH
• History, 19th Century MeSH
• Family Practice history   MeSH
• Check Tag
• History, 19th Century MeSH
• Publication type
• Biography MeSH
• Journal Article MeSH
• Historical Article MeSH
• Geographicals
• Czechoslovakia MeSH

• About
• Stanĕk, V

• MeSH
• History, 19th Century MeSH
• Check Tag
• History, 19th Century MeSH
• Publication type
• Biography MeSH
• Journal Article MeSH
• Historical Article MeSH
• Geographicals
• Czechoslovakia MeSH

• About
• Stanĕk, V

• MeSH
• History, 20th Century MeSH
• History of Pharmacy MeSH
• Check Tag
• History, 20th Century MeSH
• Publication type
• Biography MeSH
• Journal Article MeSH
• Historical Article MeSH
• Geographicals
• Czechoslovakia MeSH

• About
• Stanĕk, J

Bull seminal vesicle ribonuclease, when added in vitro to the suspension of ascitic leukaemic cells EL-4 and BP-8 for 2 hours at 37 degrees C and then transplanted to the abdominal cavities of mice, inhibitied the proliferation of these cells in vivo. When the temperature of the medium was decreased to 25 degrees C, AS RNase was bound to the leukaemic cell surfaces, but it exerted no inhibitory effect on BP-8 cells and showed a partial effect on EL-4 cells even after 24 hours. AS RNase administered to mice with leukaemic cells in diffusion chambers significantly decreased the number of cells inside the chambers as compared to the controls. The number of ascites cells was also significantly reduced after the injection of AS RNase for 1 week into mice with leukaemic cells implanted in the abdominal cavities. The reduction of cells in ascitic fluid did not cause a significant prolongation of survival of experimental mice. Only mice with transplanted BP-8 cells had significantly less cells in ascitic fluid and their survival was prolonged to 48 days in comparison with 25 days' survival in control mice after administration of pure AS RNase. In addition, AS RNase depressed the growth of solid tumours BP-8 and EL-4. AS RNase did not change the weight of body organs except the testes. Absorption experiments showed increased absorption of AS RNase by leukaemic cells BP-8 and EL-4 and by testes and spleen homogenates as compared with other body organs.

• MeSH
• Leukemia, Experimental metabolism   MeSH
• Rabbits MeSH
• Rats MeSH
• Guinea Pigs MeSH
• Mice, Inbred C3H MeSH
• Mice, Inbred C57BL MeSH
• Mice MeSH
• Ribonucleases metabolism   pharmacology   MeSH
• Seminal Vesicles enzymology   MeSH
• Cell Survival drug effects   MeSH
• Animals MeSH
• Check Tag
• Rabbits MeSH
• Rats MeSH
• Guinea Pigs MeSH
• Male MeSH
• Mice MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Ribonucleases MeSH

• MeSH
• Angina Pectoris drug therapy   MeSH
• Calcium Channel Blockers therapeutic use   MeSH
• Myocardial Infarction drug therapy   MeSH
• Rats MeSH
• Humans MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Calcium Channel Blockers MeSH

• MeSH
• Acute Disease MeSH
• Adult MeSH
• Hemodynamics * MeSH
• Myocardial Infarction physiopathology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Aged MeSH
• Oxygen Consumption MeSH
• Heart Rate MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• English Abstract MeSH
• Journal Article MeSH