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Autor: Kolmau, Reman

1 záznamů v PubMed Filtry

Článek

Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication

John, Lucy N
Autor John, Lucy N From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Beiras, Camila G
Autor Beiras, Camila G From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Houinei, Wendy
Autor Houinei, Wendy From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Medappa, Monica
Autor Medappa, Monica From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Sabok, Maria
Autor Sabok, Maria From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Kolmau, Reman
Autor Kolmau, Reman From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Jonathan, Eunice
Autor Jonathan, Eunice From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Maika, Edward
Autor Maika, Edward From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Wangi, James K
Autor Wangi, James K From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)
Pospíšilová, Petra
Autor Pospíšilová, Petra From the National Department of Health, Aopi Centre (L.N.J., W.H.), the School of Medicine and Health Sciences, University of Papua New Guinea (L.N.J., O.M.), and the World Health Organization Representative Office in Papua New Guinea (J.K.W.), Port Moresby, the New Ireland Provincial Health Authority, Kavieng (M.S., E.J., E.M.), and Lihir Medical Center, International SOS, Lihir Island (R.K., O.M.) - all in Papua New Guinea; the Infectious Diseases Department and Fight AIDS and Infectious Diseases Foundation, Hospital Universitari Germans Trias i Pujol (L.N.J., C.G.B., D.O., B.C., M.V.-M., O.M.), the Genomes for Life-Genomes of Catalonia Lab Group, Institute for Health Science Research Germans Trias i Pujol (I.G.-F.), and the IrsiCaixa AIDS Research Institute (B.C.), Badalona, the Barcelona Institute for Global Health, Faculty of Medicine, University of Barcelona (L.N.J.), and the Institute for Research in Biomedicine, Barcelona Institute of Science and Technology (I.G.-F.), Barcelona, and Universitat de Vic-Universitat Central de Catalunya, Vic (B.C., O.M.) - all in Spain; the Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic (M. Medappa, P.P., D.Š.); the Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton (M.A.B.), and the Clinical Research Department, London School of Hygiene and Tropical Medicine, and the Hospital for Tropical Diseases, University College London Hospitals, London (M. Marks) - all in the United Kingdom; the Department of Medicine, Division of Allergy and Infectious Diseases, and the Department of Global Health, University of Washington, Seattle (L.G.); and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (E.Q.M.)

The New England journal of medicine. 2022 Jan 06 ; 386 (1) : 47-56.

N Engl J Med
ISSN 1533-4406 | 0028-4793
Zdroj

BACKGROUND: Treponema pallidum subspecies pertenue causes yaws. Strategies to better control, eliminate, and eradicate yaws are needed. METHODS: In an open-label, cluster-randomized, community-based trial conducted in a yaws-endemic area of Papua New Guinea, we randomly assigned 38 wards (i.e., clusters) to receive one round of mass administration of azithromycin followed by two rounds of target treatment of active cases (control group) or three rounds of mass administration of azithromycin (experimental group); round 1 was administered at baseline, round 2 at 6 months, and round 3 at 12 months. The coprimary end points were the prevalence of active cases of yaws, confirmed by polymerase-chain-reaction assay, in the entire trial population and the prevalence of latent yaws, confirmed by serologic testing, in a subgroup of asymptomatic children 1 to 15 years of age; prevalences were measured at 18 months, and the between-group differences were calculated. RESULTS: Of the 38 wards, 19 were randomly assigned to the control group (30,438 persons) and 19 to the experimental group (26,238 persons). A total of 24,848 doses of azithromycin were administered in the control group (22,033 were given to the participants at round 1 and 207 and 2608 were given to the participants with yaws-like lesions and their contacts, respectively, at rounds 2 and 3 [combined]), and 59,852 doses were administered in the experimental group. At 18 months, the prevalence of active yaws had decreased from 0.46% (102 of 22,033 persons) at baseline to 0.16% (47 of 29,954 persons) in the control group and from 0.43% (87 of 20,331 persons) at baseline to 0.04% (10 of 25,987 persons) in the experimental group (relative risk adjusted for clustering, 4.08; 95% confidence interval [CI], 1.90 to 8.76). The prevalence of other infectious ulcers decreased to a similar extent in the two treatment groups. The prevalence of latent yaws at 18 months was 6.54% (95% CI, 5.00 to 8.08) among 994 children in the control group and 3.28% (95% CI, 2.14 to 4.42) among 945 children in the experimental group (relative risk adjusted for clustering and age, 2.03; 95% CI, 1.12 to 3.70). Three cases of yaws with resistance to macrolides were found in the experimental group. CONCLUSIONS: The reduction in the community prevalence of yaws was greater with three rounds of mass administration of azithromycin at 6-month intervals than with one round of mass administration of azithromycin followed by two rounds of targeted treatment. Monitoring for the emergence and spread of antimicrobial resistance is needed. (Funded by Fundació "la Caixa" and others; ClinicalTrials.gov number, NCT03490123.).

MeSH
antibakteriální látky aplikace a dávkování MeSH
azithromycin aplikace a dávkování MeSH
bakteriální léková rezistence MeSH
dítě MeSH
frambézie farmakoterapie epidemiologie MeSH
Haemophilus ducreyi izolace a purifikace MeSH
kojenec MeSH
kožní vředy mikrobiologie MeSH
lidé MeSH
masová profylaxe * MeSH
mladiství MeSH
polymerázová řetězová reakce MeSH
předškolní dítě MeSH
prevalence MeSH
Treponema izolace a purifikace MeSH
Check Tag
dítě MeSH
kojenec MeSH
lidé MeSH
mladiství MeSH
mužské pohlaví MeSH
předškolní dítě MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
klinické zkoušky, fáze III MeSH
multicentrická studie MeSH
práce podpořená grantem MeSH
randomizované kontrolované studie MeSH
Geografické názvy
Papua Nová Guinea epidemiologie MeSH
Názvy látek
antibakteriální látky MeSH
azithromycin MeSH

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