The transfer of information between individuals is fundamental to living systems and requires comprehensive research in various species. Weakly electric fish, Gnathonemus petersii, provides a unique model organism for such investigations due to its advanced electrocommunication via electric organ discharges (EODs). As separating EODs from multiple individuals remains challenging, we developed an unsupervised approach for EOD separation in two free-swimming individuals. Using continuous wavelet transform, t-distributed Stochastic Neighbor Embedding, and hierarchical clustering, we achieved accurate discrimination of EODs without the necessity of any training data. This approach overcomes the supervised algorithms based on previously published methods in accuracy and computational efficiency, simplifies experimental procedures, and supports animal well-being by reducing the number of required measurements. We applied our separation approach in a dyadic fish model, where ketamine was used to induce schizophrenia-like behavior in one fish. We confirmed the ketamine-induced alteration of the intrinsic relationship between locomotion and EOD signaling. Moreover, while ketamine-induced changes in locomotion were socially transferred, correlated changes in EOD signaling were not observed between dyad members, which may be interpreted as a communication deficit. Additionally, we introduced two techniques for EOD sonification, facilitating exploratory analysis of EOD sequences. These advancements lay the groundwork for future studies of EOD-based communication, highlighting the potential of Gnathonemus petersii in neuroethological, psychopharmacological, and translational research.

• Klíčová slova
• Gnathonemus Petersii, Electrocommunication, Ketamine, Schizophrenia, Sonification, Unsupervised learning,
• MeSH
• algoritmy MeSH
• chování zvířat * fyziologie   MeSH
• elektrické orgány * fyziologie   MeSH
• elektrické ryby * fyziologie   MeSH
• komunikace zvířat * MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND/OBJECTIVES: Cancer- or chemotherapy-related cognitive deficit is a common side effect occurring in patients with Hodgkin lymphoma. No previous study compared the influence of different types of treatment on the onset and development of chemotherapy cognitive impairment in longitudinal design. The aim of this study was to assess whether a more intensive form of chemotherapy causes greater cognitive impairment. METHODS: Forty-four patients at three different stages of the disease and with three different treatments (ABVD + 30 Gy, BEACOPPesc, or ABVD + 30 Gy plus BEACOPPesc) completed the neuropsychological battery and psychological measures of affective distress and quality of life. We compared their cognitive performance before, immediately after, and 6 months after the treatment. RESULTS: Whether or not we divided the total number of people with Hodgkin lymphoma into two groups (mild and moderate disease versus severe disease) or three groups (mild, moderate, and advanced disease), we found no statistically significant difference between the groups in cognitive performance or other psychological factors or experienced quality of life. CONCLUSIONS: Our results did not show that disease stage or treatment protocol had an effect on the depth of cognitive impairment in cancer or chemotherapy. We hypothesize that, in terms of brain health, intensive forms of chemotherapy (6 × BEA-COPPesc) do not pose a greater risk than milder forms (4 × ABVD + 30 Gy IF RT and 2 × BEACOPPesc + 4 × ABVD + 30 Gy IF RT) of cancer treatment for Hodgkin lymphoma. However, a limitation of our study is the small number of participants in the study, so it would be advisable to repeat the study on a larger sample of patients. Confirmation of our results could be beneficial in that neither patients nor physicians need to worry that intensive chemotherapy will worsen cognitive deficits.

• Klíčová slova
• Hodgkin lymphoma, cancer, cancer-related cognitive impairment, chemotherapy, chemotherapy-related cognitive impairment, cognitive functions,
• Publikační typ
• časopisecké články MeSH