Despite progress in understanding the role of monocarboxylate transporters (MCTs) in lactate (LA) accumulation and removal, it remains unclear whether MCT2 and MCT4 variants enhance LA utilization. This study assessed associations between MCT2 (rs3763980, rs995343, rs3763979) and MCT4 (rs11323780) polymorphisms and LA concentration. A total of 337 male athletes from the Czech Republic and Poland, divided into elite, sub-elite, and physically active individuals, completed two all-out Wingate tests. Before these tests, DNA was collected and analyzed for single-nucleotide polymorphisms (SNPs). LA concentrations were measured before and after the tests. MCT2 rs995343 showed the broadest associations. It was significantly associated with resting LA (LArest) in the overall cohort (codominant: false discovery rate (FDR)-adjusted p = 0.04; dominant: FDR-adjusted p = 0.03) and with peak LA concentration (LAmax), accumulation (ACC), and clearance (DCC) in the physically active group (all models: FDR-adjusted p = 0.02-0.04). MCT2 rs3763980 was associated with LArest in the overall group (codominant and recessive: FDR-adjusted p = 0.04). MCT2 rs3763979 was associated with LArest (FDR-adjusted p = 0.009-0.003) and LA30' (FDR-adjusted p = 0.003-0.04) in the overall and physically active cohorts. MCT4 rs11323780 was associated with LArest in elite athletes (recessive: FDR-adjusted p = 0.03) and with ACC in the physically active group (codominant and recessive: FDR-adjusted p = 0.03). These findings indicate that MCT polymorphisms contribute to variability in LA metabolism, influencing anaerobic performance and recovery.

• Klíčová slova
• athletic training, elite athletes, genetic variants, genotype, lactate kinetics, physical activity, sprint, sub-elite athletes,
• MeSH
• cvičení * fyziologie   MeSH
• dospělí MeSH
• jednonukleotidový polymorfismus * MeSH
• kinetika MeSH
• kyselina mléčná * krev   MeSH
• lidé MeSH
• mladý dospělý MeSH
• přenašeče monokarboxylových kyselin * genetika   MeSH
• sportovci MeSH
• svalové proteiny * genetika   MeSH
• symportéry genetika   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• kyselina mléčná * MeSH
• přenašeče monokarboxylových kyselin * MeSH
• SLC16A2 protein, human MeSH Prohlížeč
• SLC16A4 protein, human MeSH Prohlížeč
• svalové proteiny * MeSH
• symportéry MeSH