The cytotoxic properties of zinc nanoparticles have been evaluated in vitro against several types of cancer. However, there is a lack of significant evidence of their activity in vivo, and a potential therapeutic application remains limited. Herein we report the effective inhibition of tumor growth by zinc nanoparticles in vivo, as the effect of the dietary intervention, after the chemical induction in a rodent model of breast cancer. Biopsy images indicated grade 1 tumors with multiple inflammatory infiltrates in the group treated with zinc nanoparticles, whereas, in the other groups, a moderately differentiated grade 2 adenocarcinoma was identified. Moreover, after the supplementation with zinc nanoparticles, the levels of several metabolites associated with cancer metabolism, important to its survival, were found to have been altered. We also revealed that the biological activity of zinc in vivo depends on the size of applied particles, as the treatment with zinc microparticles has not had much effect on cancer progression.
- Klíčová slova
- breast cancer, metabolomic, zinc nanoparticles,
- MeSH
- adenokarcinom metabolismus patologie prevence a kontrola MeSH
- kovové nanočástice aplikace a dávkování analýza MeSH
- krysa rodu Rattus MeSH
- nádory prsu metabolismus patologie prevence a kontrola MeSH
- nanotechnologie MeSH
- oxid zinečnatý chemie MeSH
- potkani Sprague-Dawley MeSH
- potravní doplňky MeSH
- protinádorové látky aplikace a dávkování analýza MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- oxid zinečnatý MeSH
- protinádorové látky MeSH
