Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of the neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H and its corresponding clinical and imaging findings still need to be fully elucidated. We present 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN). PPY-H was analyzed with the help of immunohistochemistry and confocal microscopy; preoperative clinical data and imaging studies were evaluated retrospectively. We observed PPY-H emerging from pancreatic ducts, and in some cases, we observed simultaneous NKX6.1 positivity in ducts and PPY-H. Additional clinical-pathological correlations suggests that gastrointestinal symptoms (e.g., epigastric pain and cholestasis) could be more related to PPY-H than to NEN hormonal production. In particular cases, SSTR2 expression was strong in PPY-H and correlated with distinguishable accumulation of activity next to NEN on 99 mTc EDDA/Hynic-TOC SPECT/CT. In another case, 18F-FDG-PET/CT showed increased metabolic activity in the area of PPY-H surrounding NEN. Our data suggest that PPY-H originates in the lining of pancreatic ducts. Confirmation of SSTR2 in PPY-H, using immunohistochemistry, suggests the utility of 99 mTc EDDA/Hynic-TOC or 68Ga-DOTA radiotracers in clinical diagnostics; however, studies with larger cohort are needed.

• Keywords
• (18)F-FDG PET/CT, (99 m)Tc EDDA/Hynic-TOC SPECT/CT, PPY, PPY-cell hyperplasia, SSTR2,
• MeSH
• Edetic Acid analogs & derivatives   MeSH
• Hyperplasia MeSH
• Humans MeSH
• Pancreatic Neoplasms * pathology   MeSH
• Neuroendocrine Tumors * pathology   MeSH
• Nuclear Medicine * MeSH
• Organotechnetium Compounds MeSH
• Pancreatic Polypeptide MeSH
• Positron Emission Tomography Computed Tomography MeSH
• Retrospective Studies MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• EDDA MeSH Browser
• Edetic Acid MeSH
• Organotechnetium Compounds MeSH
• Pancreatic Polypeptide MeSH