A monoclonal antibody, VI-01, to vimentin and desmin has been isolated from a fusion of mouse myeloma cells with immune spleen cells. The antibody appeared specific for vimentin of various species and smooth muscle desmin and did not recognize other intermediate filament proteins when cell lines and tissue sections were assayed in immunofluorescence and cell lysates in immunoblotting. The binding test with purified vimentin and desmin confirmed these results. The antibody can differentiate carcinomas from sarcomas in human diagnostic surgical pathology.

• MeSH
• buněčné linie MeSH
• desmin imunologie   MeSH
• druhová specificita MeSH
• epitopy MeSH
• hladké svalstvo imunologie   MeSH
• křečci praví MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• monoklonální protilátky * MeSH
• myši MeSH
• vimentin imunologie   MeSH
• zvířata MeSH
• Check Tag
• křečci praví MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• desmin MeSH
• epitopy MeSH
• monoklonální protilátky * MeSH
• vimentin MeSH