BACKGROUND: Pharmacological approach is the most effective way of treatment of ADHD and its early application prevents from the progress of secondary disorders. The study on present neurotransmitter systems in pathology of ADHD can be helpful in selecting appropriate drug, since there are used various substances with different mechanisms of functioning in treatment of the hyperkinetic syndrome. METHOD: Within our study there were selected the genes of dopaminergic (DRD2, DRD3, DAT1), noradrenergic (DBH) and serotoninergic (5-HTT) systems. With the use of molecular-genetic methods based on association strategy "case-control" there were analysed genes including 11 polymorphisms. The presence of risk alleles was examined in comparison of the sample of 100 ADHD children to a control group of another 100 subjects, who were checked by child psychiatrists and examined with the Conners test in order to exclude eventual cases with ADHD symptoms. RESULTS: Our research suggests the association of some genes with ADHD. It could be concluded: 1) the risk of ADHD is significantly increased in the presence of one risk allele in genes DRD2 (O.R.=7,5), 5-HTT (O.R.=2,7) and DAT1 (O.R.=1,6). 2) The risk of ADHD is significantly increased at homozygotes for risk alleles in genes DRD2 (O.R.=54,8), 5-HTT (O.R.=6,7) and DAT1 (O.R.=6,6). For polymorphisms G444A and C1603T in DBH, which were detected by univariant analysis, haplotype analysis was performed and resulted in conclusion that: 3) the risk of ADHD is significantly increased in the presence of allele DBH +444A as well as in the presence of allele DBH +1603T (O.R.=15).

• MeSH
• dítě MeSH
• dopamin-beta-hydroxylasa genetika   MeSH
• frekvence genu MeSH
• genetická predispozice k nemoci MeSH
• hyperkinetická porucha genetika   MeSH
• jednonukleotidový polymorfismus * MeSH
• lidé MeSH
• membránové transportní proteiny pro serotonin genetika   MeSH
• mutační analýza DNA MeSH
• proteiny přenášející dopamin přes plazmatickou membránu genetika   MeSH
• receptory dopaminu D2 genetika   MeSH
• receptory dopaminu D3 genetika   MeSH
• rizikové faktory MeSH
• studie případů a kontrol MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• dopamin-beta-hydroxylasa MeSH
• DRD3 protein, human MeSH Prohlížeč
• membránové transportní proteiny pro serotonin MeSH
• proteiny přenášející dopamin přes plazmatickou membránu MeSH
• receptory dopaminu D2 MeSH
• receptory dopaminu D3 MeSH
• SLC6A3 protein, human MeSH Prohlížeč
• SLC6A4 protein, human MeSH Prohlížeč