AGREE II Dotaz Zobrazit nápovědu
Background: Charcot neuro-osteoarthropathy (CNO) is a rare but devastating complication of diabetes associated with high rates of morbidity; yet, many nonfoot specialists are unaware of it, resulting in missed and delayed diagnosis. Clinical practice guidelines (CPGs) have proven useful in improving quality of care and standardizing practice in diabetes and diabetic foot care. However, little is known about the consistency in recommendations for identification and management of active CNO. Aim: The aim of this study is to review European national diabetes CPGs for the diagnosis and management of active CNO and to assess their methodological rigor and transparency. Methods: A systematic search was performed to identify diabetes national CPGs across Europe. Guidelines in any language were reviewed to explore whether they provided a definition for active CNO and recommendations for diagnosis, monitoring, and management. Methodological rigor and transparency were assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE-II) tool, which comprises 23 key items organized within six domains with an overall guideline assessment score of ≥ 60% considered to be of adequate quality to recommend use. Each guideline was assessed by two reviewers, and inter-rater agreement (Kendall's W) was calculated for AGREE-II scores. Results: Seventeen CPGs met the inclusion criteria. Breadth of CNO content varied across guidelines (median (IQR) word count: 327; Q1 = 151; Q3 = 790), and 53% provided a definition for active CNO. Recommendations for diagnosis and monitoring were provided by 82% and 53%, respectively, with offloading being the most common management recommendation (88%). Four guidelines (24%) reached threshold for recommendation for use in clinical practice (≥ 60%) with the scope and purpose domain scoring highest (mean (SD): 67%, ± 23%). The remaining domains had average scores ranging between 19% and 53%. Inter-rater agreement was strong (W = 0.882; p < 0.001). Conclusions: European national CPGs for diabetes provide limited recommendations on active CNO. All guidelines showcased deficits in their methodology, suggesting that more rigorous methods should be employed for diabetes CPG development across Europe.
- Klíčová slova
- Charcot foot, Charcot neuro-osteoarthropathy, Clinical guideline, Diabetic foot, European guidelines,
- MeSH
- diabetická noha terapie diagnóza MeSH
- diabetické neuropatie terapie diagnóza MeSH
- lidé MeSH
- medicína založená na důkazech MeSH
- neuropatická artropatie * terapie diagnóza MeSH
- směrnice pro lékařskou praxi jako téma * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Geografické názvy
- Evropa MeSH
We introduce a computer implementation of the mathematical model of capillary zone electrophoresis described in the previous paper in this issue (Hruška et al., Electrophoresis 2012, 33), the program PeakMaster 5.3. The computer model calculates eigenmobilities, which are the eigenvalues of the Jacobian matrix of the electromigration system, and which are responsible for the presence of system eigenzones (system zones, system peaks). The model also calculates parameters of the background electrolyte: pH, conductivity, buffer capacity, ionic strength, etc., and parameters of the separated analytes: effective mobility, transfer ratio, molar conductivity detection response, and relative velocity slope. In addition to what was possible in the previous versions of PeakMaster, Version 5.3 can predict the shapes of the system peaks even for a complex injected sample profile, such as a rectangular plug. PeakMaster 5.3 can replace numerical simulation in many practically important configurations and the results are obtained in a very short time (within seconds). We demonstrate that the results obtained in real experiments agree well with those calculated by PeakMaster 5.3.
- MeSH
- elektroforéza * MeSH
- elektrolyty MeSH
- koncentrace vodíkových iontů MeSH
- kyselina benzoová MeSH
- nelineární dynamika * MeSH
- počítačová simulace MeSH
- teoretické modely * MeSH
- tromethamin MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- elektrolyty MeSH
- kyselina benzoová MeSH
- tromethamin MeSH
Spectrum-averaged cross sections (SACS) is an important quantity usable in validation of nuclear cross sections. Especially in case of dosimetrical reactions there is a request on precise validation. This paper presents SACS measured in the reference 252Cf(sf) neutron field for neutron dosimetry reactions to validate recently updated IRDFF-II library intended mainly for neutron metrology applications. It covers 46Ti(n,p)46Sc, 47Ti(n,p)47Sc, 48Ti(n,p)48Sc, 58Ni(n,p)58Co, 60Ni(n,p)60Co, 58Ni(n,2n)57Ni, 24Mg(n,p)24Na, 27Al(n,α)24Na and 63Cu(n,α)60Co threshold reactions. Measurement of 60Ni(n,p)60Co SACS is included in NEA's High Priority Nuclear Data Request List since existing data are discrepant. Spectral averaged cross sections were derived from experimentally determined reaction rates by gamma spectrometry using a same high-purity germanium detector to measure all irradiated samples. Measured spectrum-averaged cross sections agree very well within quoted uncertainties with those calculated using the IRDFF-II library. No other library achieves such good performance. Thus, the presented data support use of the cross sections of the mentioned reactions from IRDFF-II library.
- Klíčová slova
- (252)Cf, IRDFF-II, Spectral averaged cross sections,
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- AGREE-II, AGREE-S, clinical practice guidelines, methodological quality, quality assessment, surgery,
- Publikační typ
- úvodníky MeSH
BACKGROUND: Surgery for obesity and metabolic diseases has been evolved in the light of new scientific evidence, long-term outcomes and accumulated experience. EAES has sponsored an update of previous guidelines on bariatric surgery. METHODS: A multidisciplinary group of bariatric surgeons, obesity physicians, nutritional experts, psychologists, anesthetists and a patient representative comprised the guideline development panel. Development and reporting conformed to GRADE guidelines and AGREE II standards. RESULTS: Systematic review of databases, record selection, data extraction and synthesis, evidence appraisal and evidence-to-decision frameworks were developed for 42 key questions in the domains Indication; Preoperative work-up; Perioperative management; Non-bypass, bypass and one-anastomosis procedures; Revisional surgery; Postoperative care; and Investigational procedures. A total of 36 recommendations and position statements were formed through a modified Delphi procedure. CONCLUSION: This document summarizes the latest evidence on bariatric surgery through state-of-the art guideline development, aiming to facilitate evidence-based clinical decisions.
- Klíčová slova
- AGREE II, Bariatric surgery, EAES, GRADE, Guidelines, Obesity,
- MeSH
- bariatrická chirurgie metody MeSH
- endoskopie metody MeSH
- lidé MeSH
- morbidní obezita chirurgie MeSH
- směrnice pro lékařskou praxi jako téma * MeSH
- společnosti lékařské MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
The temperature dependence of the effective kinematic viscosity of turbulent He II, nu(eff)(T) , is deduced from second sound attenuation data using the late stage of decay of thermally induced counterflow He II turbulence in two channels of square cross section. It is shown to qualitatively agree with the published data for nu(eff)(T) calculated based on experiments on decaying-grid-generated He II turbulence [Niemela, J. Low Temp. Phys. 138, 537 (2005)]. Corrections to these data due to the "sine squared" law that describes attenuation of the second sound wave propagating along an arbitrary direction with respect to the direction of the core of a quantized vortex in turbulent He II are discussed and applied.
- Publikační typ
- časopisecké články MeSH
It has been recently suggested that compensatory changes in Photosystem II (PS II) electron turnover rates can protect photosynthesis from photoinhibition [Behrenfeld et al. (1998) Photosynth Res 58: 259-268]. We have further explored this feature of PS II using a rate electrode for simultaneous measurements of the steady-state rate of oxygen evolution and the oxygen flash yield depending on the background irradiance in both control and photoinhibited algal cells of Chlorella Böhm. Theoretical simulations based on the two-electron gate model agree qualitatively with experimental data if we assume an increase of the electron turnover rate in the remaining functional PS II centers of the photoinhibited sample. Our results confirm the hypothesis that the compensatory effect enables cells to maintain the maximal rates of photosynthesis even in the presence of moderate photoinhibition (decrease of up to 50% in the number of functional centers) and that the effect originates from the inner capacity of electron transport through PS II. The origin of the compensatory effect is briefly discussed.
- Publikační typ
- časopisecké články MeSH
Properties of the tetraphenylcyclobutadienecyclopentadienylnickel(II) cation 1 and its tetra-o-fluoro derivative 1a have been measured and calculated. The B3LYP/TZP optimized geometry of the free cation 1 agrees with a single-crystal X-ray diffraction structure except that in the crystal one of the phenyl substituents is strongly twisted to permit a close-packing interaction of two of its hydrogens with a nearby BF4(-) anion. The low-energy parts of the solution electronic absorption and magnetic circular dichroism (MCD) spectra of 1 and 1a have been interpreted by comparison with TD-DFT (B3LYP/TZP) results. Reduction or pulse radiolysis lead to a neutral 19-electron radical, whose visible absorption and MCD spectra have been recorded and interpreted as well. The reduction is facilitated by ∼0.1 V upon going from 1 to 1a. Unsuccessful attempts to prepare several other aryl substituted derivatives of 1 by the classical synthetic route are described in the Supporting Information .
- Publikační typ
- časopisecké články MeSH
In the present study, we have investigated complexes of CK2 protein kinase with halogenated inhibitors by means of the advanced semiempirical quantum mechanical (SQM) PM6 method (called PM6-DH2X), which describes various types of noncovalent interactions including halogen bonding well. The PM6-DH2X method provides reliable geometries of those CK2 protein kinase-inhibitor complexes involving halogen bonds that agree well with the X-ray crystal structures. When the Amber empirical potential is applied, this agreement becomes considerably worse. Similarly, the binding free energies determined by the PM6-DH2X SQM method are much closer to the experimental inhibition constants than those based on the Amber empirical potential.
- MeSH
- halogenace MeSH
- halogeny chemie MeSH
- inhibitory enzymů chemie metabolismus MeSH
- kaseinkinasa II antagonisté a inhibitory chemie MeSH
- konformace proteinů MeSH
- kvantová teorie * MeSH
- molekulární modely * MeSH
- molekulární struktura MeSH
- termodynamika MeSH
- vazba proteinů MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- halogeny MeSH
- inhibitory enzymů MeSH
- kaseinkinasa II MeSH
The authors summarize their first experiences with DNA analysis of defective low density lipoprotein receptor (LDLR) gene of the familial hypercholesterolemia heterozygotes that were selected from the III. Medical Clinic of the 1st Medical Faculty in Prague patients group. First genotype studies of unrelated FH individuals were performed by restriction fragment length polymorphism (RFLP) method. Relative allele frequencies of PvuII (0.69) and StuI (0.91) restriction enzymes agree with the world literature datas, in the ApaLI (0.69) case the higher value may be caused by, for the present, small number of analyzed patients. Possibilities of DNA analysis for pedigree FH diagnosis were demonstrated on the PvuII restriction enzyme case. By the use of polymerase chain reaction (PCR) DNA diagnosis of the familial defective apolipoprotein (Apo) B-100 (exon 26) was performed. 43 unrelated FH individuals were screened and none defective ApoB-100 gene was recorded.
- MeSH
- apolipoprotein B-100 MeSH
- apolipoproteiny B genetika MeSH
- genetické markery MeSH
- hyperlipoproteinemie typ II diagnóza genetika MeSH
- lidé MeSH
- polymerázová řetězová reakce MeSH
- polymorfismus délky restrikčních fragmentů MeSH
- polymorfismus genetický MeSH
- receptory LDL genetika MeSH
- rodokmen MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- apolipoprotein B-100 MeSH
- apolipoproteiny B MeSH
- genetické markery MeSH
- receptory LDL MeSH
