IGF-I, HGF, TGFbeta1, bFGF and VEGF are involved in the pathogenesis of thyroid gland tumors and their growth. We decided to find whether changes in the production of these cytokines by thyroid tumor cells are reflected by changes of their peripheral blood. Using ELISA kits, we measured the concentrations of growth factors in the peripheral blood serum in 28 patients with thyroid gland tumors (14 adenomas, 14 papillary carcinomas) and compared these concentrations with those in healthy people. We found significantly lower serum levels of IGF-I in patients with thyroid adenoma compared to the healthy population. Serum levels of HGF and bFGF were significantly higher in patients with thyroid adenoma and papillary carcinoma compared with those in healthy subjects. Serum concentrations of TGFbeta1 and VEGF were not significantly different in any groups of investigated subjects. Changes in the production of these cytokines by thyroid gland tumor cells are reflected in their peripheral blood levels, but these levels also depend on a number of other physiological and pathological processes in the organism. However, significant differences of HGF and bFGF serum levels can be explained by their very high production by thyroid tumor cells and by their strong effect on the follicular and endothelial cell proliferation.

• MeSH
• adenom krev   MeSH
• fibroblastový růstový faktor 2 krev   MeSH
• hepatocytární růstový faktor krev   MeSH
• insulinu podobný růstový faktor I metabolismus   MeSH
• lidé MeSH
• nádorové biomarkery krev   MeSH
• nádory štítné žlázy krev   MeSH
• papilární karcinom krev   MeSH
• patologická angiogeneze krev   MeSH
• růstové látky krev   MeSH
• transformující růstový faktor beta krev   MeSH
• transformující růstový faktor beta1 MeSH
• vaskulární endoteliální růstový faktor A krev   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• fibroblastový růstový faktor 2 MeSH
• hepatocytární růstový faktor MeSH
• insulinu podobný růstový faktor I MeSH
• nádorové biomarkery MeSH
• růstové látky MeSH
• TGFB1 protein, human MeSH Prohlížeč
• transformující růstový faktor beta MeSH
• transformující růstový faktor beta1 MeSH
• vaskulární endoteliální růstový faktor A MeSH

OBJECTIVE: Angiogenic growth factors bFGF and VEGF ensure vascularisation of the growing tumor tissue. We decided to investigate their peripheral serum concentrations in patients with thyroid gland adenoma and papillary carcinoma and with parathyroid adenoma. We wanted to find the possible serum marker of these tumor diseases. METHODS: 28 patients with thyroid gland tumor (14x adenoma, 14x papillary carcinoma) and 12 patients with parathyroid gland adenoma. Growth factors serum levels were measured by ELISA method. RESULTS: We found significantly higher serum levels of bFGF in both groups of patients with thyroid adenoma (4.93 +/- 3.42 ng/ml) and papillary carcinoma (5.69 +/- 5.58 ng/ml) compared to the healthy population (1.47 +/- 1.77 ng/ml). There were no significant differences of VEGF serum levels between all examined groups of patients (adenoma 213 +/- 197, papillary carcinoma 210 +/- 179, healthy 227 +/- 231 pg/ml). We found significantly higher serum levels of bFGF in patients with parathyroid gland adenoma (7.59 +/- 9.12 ng/ml) compared to those in healthy people (1.47 +/- 1.77 ng/ml). CONCLUSIONS: Higher bFGF serum concentrations in patients with thyroid and parathyroid tumors are in accordance with their immunohistochemical tissue levels described in the literature. Not so in VEGF. bFGF may be a serum marker of thyroid and parathyroid neoplasms.

• MeSH
• adenom krev   MeSH
• biologické markery MeSH
• fibroblastový růstový faktor 2 krev   MeSH
• lidé MeSH
• nádorové biomarkery MeSH
• nádory příštítného tělíska krev   MeSH
• nádory štítné žlázy krev   MeSH
• papilární karcinom krev   MeSH
• patologická angiogeneze krev   MeSH
• vaskulární endoteliální růstový faktor A krev   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• biologické markery MeSH
• fibroblastový růstový faktor 2 MeSH
• nádorové biomarkery MeSH
• vaskulární endoteliální růstový faktor A MeSH