After lindane was administered to rats in a single oral dose, the time profile of the degree of conjugation of the main phenolic metabolites was evaluated. In all urine samples 2,3-dichlorophenol, 2,4,5- and 2,4,6-trichlorophenol, and 2,3,5,6-tetrachlorophenol were constantly present. 2,3,5,6-Tetrachlorophenol and then 2,4,6-trichlorophenol were the prevalent metabolites in all cases. The degree of conjugation did not correlate with the dissociation constant of individual chlorinated phenols. Phenol conjugation declined with time after administration.

• MeSH
• aplikace orální MeSH
• časové faktory MeSH
• chlorfenoly metabolismus   moč   MeSH
• chromatografie plynová metody   MeSH
• elektrochemie MeSH
• hexachlorcyklohexan aplikace a dávkování   metabolismus   MeSH
• inbrední kmeny potkanů MeSH
• krysa rodu Rattus MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• chlorfenoly MeSH
• hexachlorcyklohexan MeSH