Clinical value of cordarone as an antiarrhythmic agent
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The antiarrhythmic efficacy of Cordarone was studied in 90 patients (64 men and 26 women) aged 16-76. Cordarone appeared to be efficacious in the treatment of resistant arrhythmias, particularly ventricular extrasystoles and paroxysmal tachycardia in the WPW syndrome. Total disappearance of dysrhythmias was achieved in 40%, and good therapeutic effects in 32% of patients (an overall 72 percent success). Rapid initial loading (800-1200 mg/day) and continuation with a maintenance dose (100-400 mg/day) may be used as an optimal therapy model. Cordarone is well tolerated even with prolonged use. Side-effects necessitated drug withdrawal in 4.4% of patients. It is possible to combine Cordarone with other selected antiarrhythmic drugs in most resistant rhythm disturbances.
- MeSH
- amiodaron škodlivé účinky terapeutické užití MeSH
- dospělí MeSH
- elektrokardiografie MeSH
- extrasystoly farmakoterapie MeSH
- fibrilace síní farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- paroxysmální tachykardie farmakoterapie MeSH
- senioři MeSH
- srdeční arytmie farmakoterapie MeSH
- supraventrikulární tachykardie farmakoterapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- amiodaron MeSH