Effect of inhalation of single dose of beclomethasone on airway epithelium
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Inhaled corticosteroids are being recommended for the treatment of bronchial asthma for their anti-inflammatory properties and reduction of airway hyperreactivity. The first tissue coming to the contact with all inhaled substances is the airway epithelium. In this experiment, the immediate effect of a single MDI dose of beclomethasone on the ultrastructure of the tracheal and bronchiolar epithelium was studied. Due to the beclomethasone administration, the secretory elements were highly affected. The tracheal goblet cells were damaged, mucus release was significantly accelerated, and the mechanism of secretion was influenced. The bronchiolar Clara cells revealed signs of the pathological alteration. Their secretory granules were usually stored in the cytoplasm. Occasionally, degenerating Clara cells were found after the beclomethasone administration. The injury of ciliated cells in both locations was only mild and this fact was reflected in slight impairment of the tracheal ciliary border. As a morphological sign of impaired self-cleaning ability, inspissated secretion was discovered among cilia. According to this evaluation, the inhalation of the single dose of beclomethasone caused a moderate damage to the tracheal epithelium and a mild one to the epithelium of terminal bronchioles. The results draw attention to the adverse effects of otherwise therapeutically beneficial inhaled glucocorticosteroids.
- MeSH
- antiastmatika škodlivé účinky MeSH
- aplikace inhalační MeSH
- beklomethason škodlivé účinky MeSH
- bronchy účinky léků metabolismus ultrastruktura MeSH
- hlen metabolismus MeSH
- inhalační expozice MeSH
- králíci MeSH
- organismy bez specifických patogenů MeSH
- pohárkové buňky účinky léků metabolismus ultrastruktura MeSH
- respirační sliznice účinky léků ultrastruktura MeSH
- transmisní elektronová mikroskopie metody MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antiastmatika MeSH
- beklomethason MeSH