The authors present the case of a female patient who, following complicated surgery, developed endogenous endophthalmitis. Based on the clinical picture and microscopic finding in the punctuate of the affected vitreous body the diagnosis of endogenous mycotic endophthalmitis was established. The treatment of the condition is based on a combination of local and systemic administration of antimycotics. If medicamentous treatment is not effective, pars plana vitrectomy must be performed. In severe cases surgical treatment is selected as soon as the diagnosis is confirmed.

• MeSH
• endoftalmitida diagnóza   farmakoterapie   etiologie   mikrobiologie   MeSH
• kandidóza * diagnóza   farmakoterapie   etiologie   MeSH
• kyčelní protézy MeSH
• lidé MeSH
• oční infekce mykotické * diagnóza   farmakoterapie   etiologie   MeSH
• pooperační komplikace MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

PURPOSE: To report clinical findings, diagnostic and treatment possibilities of patients with endogenous fungal endophthalmitis (EFE). METHODS: Retrospective study of 13 patients (19 eyes) with EFE diagnosed and treated in the Dept. of Ophthalmology, 1st Medical Faculty, Charles University in Prague. A detailed personal medical history was taken in all patients. Standard ophthalmic examinations were performed in all cases. RESULTS: All of our patients had one or more of known risk factors for ocular fungal infections. There were intravenous drug users, immunosuppressed patients, postoperative patients receiving broad-spectrum antibiotics in our investigated group. The mean age of the patients was 39 years (from 19 to 68 years), the interval between the first ocular symptoms and correct diagnosis was up to 7 months (mean 2.1 months). Pars plana vitrectomy (PPV) was performed in 15 eyes and Amphotericin B was instilled into vitreous cavity at the end of the procedure. Amphotericin B was injected into vitreous without PPV in two eyes. All patients were treated with systemic antifungal agents. Only Candida albicans was the cause of EFE in 10 patients. Microscopic examination and culture were positive in 9 patients, 1 patient had positive serum antibodies against Candida albicans in significant titres. Final visual acuity improved in 47% of the eyes, stabilized in 36% of the eyes, and decreased in 17% of the eyes. CONCLUSION: Endogenous fungal endophthalmitis was seen as an opportunistic disease in all patients. Candida albicans was the only evidenced cause of fungal endophthalmitis. If prompt antifungal treatment after clinical suspicion of EFE begins, successful visual outcome is possible.

• MeSH
• antifungální látky terapeutické užití   MeSH
• dospělí MeSH
• endoftalmitida farmakoterapie   chirurgie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• oční infekce mykotické farmakoterapie   chirurgie   MeSH
• oportunní infekce farmakoterapie   chirurgie   MeSH
• retrospektivní studie MeSH
• senioři MeSH
• vitrektomie * MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• antifungální látky MeSH