• MeSH
• antibakteriální látky terapeutické užití   MeSH
• infekční nemoci farmakoterapie   MeSH
• kontrola infekčních nemocí * MeSH
• lidé MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Geografické názvy
• Československo MeSH
• Názvy látek
• antibakteriální látky MeSH

INTRODUCTION: The study objective was to evaluate epidemiological aspects in patients with hepatitis C treated at the Clinic of Infectology and Travel Medicine in Kosice. MATERIAL AND METHODS: A retrospective analysis was performed of 232 patients (132 males and 100 females, mean age 43.8 years) followed up and treated with the diagnosis of hepatitis C (HC) in 2003 through 2007. RESULTS: The probable sources of infection were most often blood transfusion (in 31% of patients), injecting drug use (9%) and invasive medical procedures (6%). Tattooing and piercing procedures were a potential route of infection in 4% of HC cases, while other risk factors were less common. None of the HC risk factors was identified in 41% of HC patients. HCV genotype was determined in 198 patients. HCV genotype 1 was detected in nearly 90% of the tested HC patients, HCV genotype 3 in 36.6%, HCV genotype 2 in 3 patients and HCV genotypes 4 and 6 in one patient each. Two HC cases were coinfections with HCV genotypes 1 and 3 or 1 and 4. The mean time interval from the first detection of elevated aminotransferase activity to the diagnosis and therapy institution was 6.3 years. CONCLUSION: The most common source of infection was blood transfusion, followed by injecting drug use and surgery. The prevailing HCV genotype is 1. In the future, it would be necessary to reduce the time interval from the detection of liver damage to the etiological diagnosis of HC, which has been too long.

• MeSH
• dospělí MeSH
• Hepacivirus klasifikace   genetika   MeSH
• hepatitida C epidemiologie   přenos   virologie   MeSH
• lidé MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Geografické názvy
• Slovenská republika epidemiologie   MeSH

AIM: To analyse clinical, laboratory, and epidemiological data of a cohort of patients with acute hepatitis E treated at the Clinic of Infectology and Travel Medicine (CITM) in Košice. MATERIAL AND METHODS: Retrospective analysis of hospital information system data on patients diagnosed with acute hepatitis E who were examined or hospitalized at CITM in 2015-2023. Statistical evaluation of the available data with a focus on epidemiology, course, and complications. RESULTS: The cohort consisted of 62 patients. Fifty-eight percent were male. The mean age was 56 years. Seventy-four percent of patients were hospitalized, with a mean length of hospital stay of 10 days. The most common clinical manifestation was jaundice (in 40% of patients). Six patients had stool HEV RNA testing and all were confirmed to have genotype 3. In 5% of patients, the infection was classified as imported (they did not have HEV RNA tested), and 95% of cases were autochthonous. A history of contact with an HEV infected person was reported by 26% of patients. A history of preexisting liver disease was noted in 13% of patients who were confirmed with higher bilirubin, GMT, and ammonia levels. No statistically significant differences were found for patients with a history of immune deficiency. One patient with preexisting liver disease developed fulminant infection resulting in death. Four hepatitis E patients with neurological symptoms had lower bilirubin levels. CONCLUSIONS: The study cohort included predominantly older men. Genotype 3 was confirmed in all patients who underwent HEV RNA testing. Higher bilirubin, ammonia, and GMT levels were confirmed in patients with preexisting liver disease. Patients with neurological complications had lower bilirubin levels. One patient with preexisting liver disease died.

• Klíčová slova
• hepatitis E, acute hepatitis E, autochthonous hepatitis E, hepatitis E,
• MeSH
• akutní nemoc MeSH
• cestovní lékařství MeSH
• dospělí MeSH
• hepatitida E * epidemiologie   diagnóza   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• retrospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• virus hepatitidy E genetika   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Itálie epidemiologie   MeSH

• MeSH
• infekční lékařství * MeSH
• lidé MeSH
• mikrobiologie * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• úvodníky MeSH

The article discusses possible prevention and prophylaxis of infectious diseases affecting the course of pregnancy with respect to the mother, fetus and newborn. Also mentioned are diseases for which there is no vaccination. The options for prevention targeted at the periods before and during pregnancy and after delivery are explained. Finally, practical procedures related to vaccination and diagnosis of infectious diseases in women of childbearing age are presented.

• MeSH
• infekční komplikace v těhotenství * diagnóza   prevence a kontrola   MeSH
• infekční lékařství metody   MeSH
• infekční nemoci * diagnóza   MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• vakcinace MeSH
• Check Tag
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH