The interaction between negatively charged lipid vesicles and positively charged DNA/polylysine complexes was studied. The interaction does not lead to release of DNA from the initial complexes. The particles formed are easy to prepare, they have slight negative charge, small dimensions and show good stability in physiological NaCl solution. Such properties might indicate that stabilization of the particles by lipid coating might be a potent strategy, alternative to PEGylation of DNA/polycation complexes. Interaction of DNA/polycation complex particles with lipid vesicles.

• MeSH
• chlorid sodný chemie   MeSH
• DNA aplikace a dávkování   chemie   MeSH
• fosfolipidy chemie   MeSH
• kationty * MeSH
• lipidové dvojvrstvy MeSH
• nanostruktury MeSH
• polylysin chemie   MeSH
• roztoky MeSH
• sérový albumin chemie   MeSH
• technika přenosu genů MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• chlorid sodný MeSH
• DNA MeSH
• fosfolipidy MeSH
• kationty * MeSH
• lipidové dvojvrstvy MeSH
• polylysin MeSH
• roztoky MeSH
• sérový albumin MeSH