OBJECTIVE: Gastrointestinal toxicity is one of the most common side effects of anticancer therapy. Measurement of intestinal permeability represents one of the potential methods of noninvasive laboratory assessment of gastrointestinal toxicity. The aim of the present study was to investigate intestinal permeability and vitamin A absorption in patients with chemotherapy-induced diarrhea (CID). METHODS: We have assessed intestinal permeability, by measuring absorption of lactulose, mannitol, xylose, and vitamin A absorption, in 11 patients with CID, 10 healthy controls, and 24 untreated patients with gastrointestinal tumors. Urinary lactulose, mannitol and xylose were measured by capillary gas chromatography and serum retinol and retinyl esters were determined by high performance liquid chromatography. The results obtained in patients and controls were compared by Mann-Whitney U test. RESULTS: Lactulose/mannitol and lactulose/xylose ratios were increased and retinol esters (retinyl palmitate and retinyl stearate) were decreased significantly in patients with CID. CONCLUSIONS: Measurements of intestinal permeability and vitamin A absorption may represent sensitive tools in the assessment of CID.

• MeSH
• dospělí MeSH
• gastrointestinální stromální tumory komplikace   farmakoterapie   patologie   MeSH
• intestinální absorpce * MeSH
• laktulosa moč   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mannitol moč   MeSH
• mladý dospělý MeSH
• nádory rekta komplikace   farmakoterapie   patologie   MeSH
• permeabilita MeSH
• prognóza MeSH
• protokoly protinádorové kombinované chemoterapie škodlivé účinky   MeSH
• průjem chemicky indukované   farmakoterapie   metabolismus   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• studie případů a kontrol MeSH
• vitamin A metabolismus   MeSH
• xylosa moč   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Názvy látek
• laktulosa MeSH
• mannitol MeSH
• vitamin A MeSH
• xylosa MeSH