In this review, we emphasize the significance of the Liebeskind-Srogl cross-coupling reaction, a palladium-catalyzed process involving the reaction between a thioester and a boronic acid. This reaction has emerged as a fundamental technique in synthetic methodologies aimed at the development of biologically active compounds. The Liebeskind-Srogl cross-coupling method has become an essential approach in chemistry, facilitating the diversification of complex structures that would be significantly more challenging to synthesize through alternative approaches. In this review, we aim to outline the numerous possibilities for preparing a wide range of derivatives, each with notable biological potential.

• Klíčová slova
• Biological activity, Catalysis, Copper, Cross-coupling, C–C bond formation, Heterocycles, Libeskind-Srogl, Medicinal chemistry, Natural products, Organometallic, Organosulfur, Palladium,
• MeSH
• katalýza MeSH
• kyseliny boronové * chemie   MeSH
• molekulární struktura MeSH
• palladium chemie   MeSH
• techniky syntetické chemie * metody   MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• kyseliny boronové * MeSH
• palladium MeSH