5-azacytidine [5-AzCR] and 5-aza-2'-deoxycytidine [5-AzCdR] can produce an immunosuppressive or an immunostimulatory effect on the graft-versus-host or host-versus-graft reactions in the regional popliteal lymph node of the mouse. The result depends on the dose of the drug and the time between its administration and induction of the cell-mediated immune response. Syngeneic spleen cells are capable of inducing regional lymphadenomegaly if injected into the footpads of recipients treated 1 day previously or concurrently with 5-AzCR or 5-AzCdR. Spleen cells from allogeneic and syngeneic donors treated with 5-AzCR or 5-AzCdR in vivo or in vitro can elicit greater regional lymphadenomegaly than the untreated cells. Both drugs not only seem to influence the proliferative activity of effector and regulatory populations of immunocompetent cells, but they probably also change their recognition ability and immunogenic properties.

• MeSH
• adjuvancia imunologická MeSH
• azacytidin analogy a deriváty   farmakologie   MeSH
• buněčná imunita účinky léků   MeSH
• decitabin MeSH
• homologní transplantace MeSH
• imunosupresiva MeSH
• inbrední kmeny myší MeSH
• myši MeSH
• reakce příjemce proti štěpu účinky léků   MeSH
• reakce štěpu proti hostiteli účinky léků   MeSH
• slezina účinky léků   imunologie   transplantace   MeSH
• techniky in vitro MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• adjuvancia imunologická MeSH
• azacytidin MeSH
• decitabin MeSH
• imunosupresiva MeSH