5-azacytidine [5-AzCR] and 5-aza-2'-deoxycytidine [5-AzCdR] can produce an immunosuppressive or an immunostimulatory effect on the graft-versus-host or host-versus-graft reactions in the regional popliteal lymph node of the mouse. The result depends on the dose of the drug and the time between its administration and induction of the cell-mediated immune response. Syngeneic spleen cells are capable of inducing regional lymphadenomegaly if injected into the footpads of recipients treated 1 day previously or concurrently with 5-AzCR or 5-AzCdR. Spleen cells from allogeneic and syngeneic donors treated with 5-AzCR or 5-AzCdR in vivo or in vitro can elicit greater regional lymphadenomegaly than the untreated cells. Both drugs not only seem to influence the proliferative activity of effector and regulatory populations of immunocompetent cells, but they probably also change their recognition ability and immunogenic properties.
- MeSH
- Adjuvants, Immunologic MeSH
- Azacitidine analogs & derivatives pharmacology MeSH
- Immunity, Cellular drug effects MeSH
- Decitabine MeSH
- Transplantation, Homologous MeSH
- Immunosuppressive Agents MeSH
- Mice, Inbred Strains MeSH
- Mice MeSH
- Host vs Graft Reaction drug effects MeSH
- Graft vs Host Reaction drug effects MeSH
- Spleen drug effects immunology transplantation MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- Azacitidine MeSH
- Decitabine MeSH
- Immunosuppressive Agents MeSH
