There is great need for coordination around standards and best practices in neuroscience to support efforts to make neuroscience a data-centric discipline. Major brain initiatives launched around the world are poised to generate huge stores of neuroscience data. At the same time, neuroscience, like many domains in biomedicine, is confronting the issues of transparency, rigor, and reproducibility. Widely used, validated standards and best practices are key to addressing the challenges in both big and small data science, as they are essential for integrating diverse data and for developing a robust, effective, and sustainable infrastructure to support open and reproducible neuroscience. However, developing community standards and gaining their adoption is difficult. The current landscape is characterized both by a lack of robust, validated standards and a plethora of overlapping, underdeveloped, untested and underutilized standards and best practices. The International Neuroinformatics Coordinating Facility (INCF), an independent organization dedicated to promoting data sharing through the coordination of infrastructure and standards, has recently implemented a formal procedure for evaluating and endorsing community standards and best practices in support of the FAIR principles. By formally serving as a standards organization dedicated to open and FAIR neuroscience, INCF helps evaluate, promulgate, and coordinate standards and best practices across neuroscience. Here, we provide an overview of the process and discuss how neuroscience can benefit from having a dedicated standards body.

• Klíčová slova
• FAIR principles, INCF, INCF endorsement process, Neuroinformatics, Neuroscience, Standards and best practices, Standards organization,
• MeSH
• neurovědy * MeSH
• reprodukovatelnost výsledků MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Research Support, N.I.H., Extramural MeSH

Research suggests that scientists display confirmation biases with regard to the evaluation of research studies, in that they evaluate results as being stronger when a study confirms their prior expectations. These biases may influence the peer review process, particularly for studies that present controversial findings. The purpose of the current study was to compare the evaluation of a parapsychology study versus a neuroscience study. One hundred participants with a background in psychology were randomly assigned to read and evaluate one of two virtually identical study abstracts (50 participants per group). One of the abstracts described the findings as if they were from a parapsychology study, whereas the other abstract described the findings as if they were from a neuroscience study. The results revealed that participants rated the neuroscience abstract as having stronger findings and as being more valid and reliable than the parapsychology abstract, despite the fact that the two abstracts were identical. Participants also displayed confirmation bias in their ratings of the parapsychology abstract, in that their ratings were correlated with their scores on transcendentalism (a measure of beliefs and experiences related to parapsychology, consciousness and reality). Specifically, higher transcendentalism was associated with more favorable ratings of the parapsychology abstract, whereas lower transcendentalism was associated with less favorable ratings. The findings suggest that individuals with a background in psychology need to be vigilant about potential biases that could impact their evaluations of parapsychology research during the peer review process.

• Klíčová slova
• Bias, Confirmation bias, Neuroscience, Parapsychology, Psi, Psychology, Research,
• MeSH
• dospělí MeSH
• kultura MeSH
• lidé MeSH
• neurovědy * MeSH
• parapsychologie * MeSH
• průzkumy a dotazníky MeSH
• psychologie MeSH
• zkreslení výsledků (epidemiologie) * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH

In the article "What are neural correlates neural correlates of?" published in the journal BioSocieties, Gabriel Abend points out that neuroscientists cannot avoid philosophical questions concerning the conceptualization and operationalization of social-psychological phenomena they deal with at the physiological level. In this article, we build on Abend's thesis and, through a systematic literature review of decision neuroscience studies, test it with the example of the social-psychological phenomenon of uncertainty in decision making. In this paper, we provide an overview of studies that appropriately attempt to conceptualise uncertainty, and then use these studies to analyse papers looking for neural correlates of uncertainty. Based on a systematic review of studies, we investigate what types of uncertainty authors in the field of decision neuroscience address and define, what criteria they use to distinguish between these types, what problems are associated with their conceptualization, and whether the neural correlates of different types of uncertainty can be accurately identified. The paper concludes that, particularly in the economic context, a collaboration between the natural and social sciences works well, and neuroscience studies use economic conceptualizations of uncertainty that are further developed by sophisticated decision tasks. However, the paper also highlights problematic aspects that obscure the understanding of the phenomena under study. These include the lack of criteria for distinguishing between different types of phenomena, the unclear use of the general concept of uncertainty, and the confusion of phenomena or their erroneous synonymous use.

• Klíčová slova
• Ambiguity, Decision neuroscience, Neural correlates, Neuroeconomics, Risk, Uncertainty,
• MeSH
• lidé MeSH
• nejistota MeSH
• neurovědy * MeSH
• rozhodování * fyziologie   MeSH
• vytváření pojmu MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• systematický přehled MeSH

State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact tissues from individual organs and even to some entire mammals. When combined with light-sheet microscopy and automated approaches to image analysis, existing tissue-clearing methods can speed up and may reduce the cost of conventional histology by several orders of magnitude. In addition, tissue-clearing chemistry allows whole-organ antibody labelling, which can be applied even to thick human tissues. By combining the most powerful labelling, clearing, imaging and data-analysis tools, scientists are extracting structural and functional cellular and subcellular information on complex mammalian bodies and large human specimens at an accelerated pace. The rapid generation of terabyte-scale imaging data furthermore creates a high demand for efficient computational approaches that tackle challenges in large-scale data analysis and management. In this Review, we discuss how tissue-clearing methods could provide an unbiased, system-level view of mammalian bodies and human specimens and discuss future opportunities for the use of these methods in human neuroscience.

• MeSH
• histologické techniky přístrojové vybavení   metody   MeSH
• lidé MeSH
• mikroskopie přístrojové vybavení   metody   MeSH
• nervový systém cytologie   MeSH
• neurovědy MeSH
• savci MeSH
• zobrazování trojrozměrné metody   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Research Support, N.I.H., Extramural MeSH

History of the study of dissociation begins in the second half of the nineteenth century. It begins in the works of Hughlings Jackson and Pierre Janet, and markedly influences development of psychoanalysis and other psychological trends. According to the modern definition, dissociation represents a disturbance or alteration in the normally integrative functions of identity, memory, or consciousness. Dissociative symptoms occur mainly due to some traumatic events and probably cannot be generally explained on the basis of neurological focal lesion. However, from recent findings, it may be inferred that temporal lobe epileptic activity is important in the generation of dissociative symptoms. Recent findings show that neural networks provide an attractive framework for modeling dissociative mental processes and dissociative mechanisms. In the article we propose a new theoretical connection among neural network models of dissociation, Freeman's model of chaos in the brain and electrophysiological findings regarding dissociative states. Concluding remarks are concerned with connections of dissociation and inter-hemispheric communication.

• MeSH
• dějiny 20. století MeSH
• disociační poruchy diagnóza   dějiny   patofyziologie   MeSH
• elektroencefalografie MeSH
• lidé MeSH
• neuronové sítě (počítačové) * MeSH
• neurovědy dějiny   trendy   MeSH
• předpověď MeSH
• psychologické modely MeSH
• psychologie dějiny   trendy   MeSH
• Check Tag
• dějiny 20. století MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• historické články MeSH

Good brain health plays a significant role in an individual's well-being and profoundly impacts the collective economy and society. Brain development does not stop at birth, and some aspects continue throughout childhood and adolescence, allowing the full development of cognitive functions. Different determinants related to physical health, healthy environments, safety and security, life-long learning and social connection as well as access to quality services influence the way our brains develop, adapt and respond to stress and adversity. Ongoing progress in neurobiology and cognitive neuroscience allows the design of better prevention and intervention strategies to help avoid brain deficits and/or limit their impact and maintain brain health. The European Brain Council (EBC) convened an expert meeting during the Federation of European Neuroscience Societies (FENS) Forum 2024 to address youth brain health challenges. In recent years, the importance of brain health has garnered significant attention across scientific, medical and policy-making communities. Although much focus has traditionally been on neurodegenerative conditions affecting the elderly, a paradigm shift towards prioritizing brain health in youth is both timely and necessary. This shift can profoundly impact individual lives and society, necessitating an interdisciplinary approach that brings neuroscience to the forefront of public health and informs evidence-based policy. The topic is of utmost importance as EBC launched this year a new campaign on No Health Without Brain Health rallying support with its member organizations and the wider brain community for the increased prioritization of brain health on EU health and research agendas.

• MeSH
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mozek * fyziologie   MeSH
• neurovědy * MeSH
• společnosti vědecké MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• Publikační typ
• úvodníky MeSH
• Geografické názvy
• Evropa MeSH

Vincenc Alexandr Bohdálek (Vincenz Alexander Bochdalek) is known primarily as an anatomist and pathologist and entered into the history of anatomy by describing a number of anatomical structures. Unfortunately his findings in the field of neuroscience are, with few exceptions, almost unknown. Current reviewtherefore partially fills a gap in the evaluation of the contributions of Bohdálek and based on available archival sources provides an overview of his results in the field of the nervous system research, which accounts for almost half of his works. He studied in detailpredominantly the innervation of eye, upper jaw, hard palate,auditory system and meninges, and surprisingly also dealt with the tissue regeneration. Bohdálek's works also show that he tried to find a physiological explanation to the observed anatomical and pathological findings, therefore he could be considered as a pioneer of the field, which is now called as func- tional anatomy. Present overview of his neuroscience works, including his complete bibliography,partially fills a huge debt to Bohdálek. Key words: nerves, brain, Bohdálek, 19th century.

• MeSH
• anatomie dějiny   MeSH
• dějiny 19. století MeSH
• lidé MeSH
• nervový systém anatomie a histologie   MeSH
• neuroanatomie dějiny   MeSH
• neurovědy dějiny   MeSH
• Check Tag
• dějiny 19. století MeSH
• lidé MeSH
• Publikační typ
• biografie MeSH
• časopisecké články MeSH
• historické články MeSH
• portréty MeSH
• Geografické názvy
• Česká republika MeSH

• O autorovi
• Bohdálek, Vincenc

Manganese (Mn) is an essential trace element with well characterized neurotoxic effects in high concentrations. Neurochemically, the initial neurotoxic effect of Mn is the perturbation of striatal γ-aminobutyric acid levels. Specific tasks for the assessment of cognitive functions subserved by fronto-striatal loops are available as the stop-change task (SCT) assessing control of multi-component behavior and action cascading. In a cross-sectional study, fifty male welders and 28 age-matched controls completed the SCT during a whole day examination. Reaction times, responses accuracy, and event-related potentials (ERPs) from electroencephalogram (EEG) recordings were analyzed. The shift exposure of the welders to respirable Mn was stratified by 20 µg/m3 in 23 low-exposed (median = 4.7 µg/m3) and 27 high-exposed welders (median = 86.0 µg/m3). Welders graduation was lower and was therefore included in the analyses. The task-related factor (stop-change delay, SCD) modified the responses as expected; however, the lack of an interaction "SCD × group" revealed no differences between welders and controls. EEG data showed that the "SCD" modulated the amplitude of the P3 ERP in controls stronger than in welders. There was no difference between the two groups of welders and no association between airborne or systemic Mn and the P3 ERP. Moreover, the P3 amplitude was smaller in subjects with lower education. These results showed that multitasking performance and cognitive flexibility are not impaired in welders. The electrophysiological results gave a weak hint that relevant neurobiological processes were different in welders as compared to controls but this may be related to lower education.

• Klíčová slova
• Cognitive functions, Electrophysiology, Manganese, Neurobehavioral testing, Toxicity,
• MeSH
• elektroencefalografie MeSH
• kognice účinky léků   MeSH
• kognitivní neurověda metody   MeSH
• látky znečišťující vzduch v pracovním prostředí analýza   toxicita   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mangan analýza   toxicita   MeSH
• neuropsychologické testy MeSH
• pracovní expozice škodlivé účinky   analýza   MeSH
• průřezové studie MeSH
• reakční čas MeSH
• studie případů a kontrol MeSH
• svařování * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• látky znečišťující vzduch v pracovním prostředí MeSH
• mangan MeSH

The collapse of the communist regime in Czechoslovakia revealed not only the disastrous state of the Czechoslovak economy but also the serious problems that Czechoslovak science faces. Understanding the present situation and determining the best way to improve it requires careful analysis of the development of science during the past 40 years.

• MeSH
• lidé MeSH
• neurologie trendy   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Československo MeSH

• MeSH
• neurovědy * MeSH
• výzkumný projekt * MeSH
• Publikační typ
• časopisecké články MeSH