A fuzzy model has been developed for the optimization of high-shear wet granulation wetting on a plant scale depending on the characteristics of pharmaceutical active substance particles. The model optimized on the basis of experimental data involves a set of rules obtained from expert knowledge and full-scale process data. The skewness coefficient of particle size distribution and the tapped density of the granulated mixture were chosen as the model input variables. The output of the fuzzy ruled system is the optimal quantity of wetting liquid. In comparison to manufacturing practice, a very strong sensitivity of the optimal quantity of the added wetting liquid to the size and shape of the active substance particles has been identified by fuzzy modeling.

• MeSH
• farmaceutická chemie MeSH
• farmaceutická technologie metody   MeSH
• fuzzy logika * MeSH
• léčivé přípravky chemie   MeSH
• pomocné látky chemie   MeSH
• rozpustnost MeSH
• smáčivost MeSH
• velikost částic MeSH
• voda chemie   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• léčivé přípravky MeSH
• pomocné látky MeSH
• voda MeSH