The phagocytosis of free Plasmodium chabaudi parasite by resident peritoneal macrophages of mouse was studied in an in vitro system. The effect of antimalarial antiserum (HIS) was assessed by preincubation of parasite macrophages and both parasite and macrophages with HIS prior to use in phagocytic assays. Highest phagocytic index was obtained with HIS pretreated parasites. The two activities viz. opsonic (parasite dependent) and cytophilic (macrophage dependent) were noted to operate independent of each other. The phagocytosis promoting activity was found to be complement dependent. The receptor site for binding of HIS opsonized but not medium opsonized parasite on the surface of macrophages was blocked by pretreatment of these cells with HIS-soluble antigen combination.

• MeSH
• antigeny protozoální imunologie   MeSH
• fagocytóza * MeSH
• kompetitivní vazba MeSH
• komplement imunologie   MeSH
• makrofágy imunologie   MeSH
• malárie imunologie   MeSH
• myši MeSH
• opsoniny imunologie   MeSH
• Plasmodium imunologie   MeSH
• protilátky imunologie   MeSH
• reakce antigenu s protilátkou MeSH
• receptory Fc imunologie   MeSH
• receptory IgG MeSH
• techniky in vitro MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antigeny protozoální MeSH
• komplement MeSH
• opsoniny MeSH
• protilátky MeSH
• receptory Fc MeSH
• receptory IgG MeSH