The authors present a case of 61-year-old man with ulcerative colitis and with extraintestinal manifestation of the disease in the form of pyoderma gangraenosum. Multiple skin defects, which developed in atypical localisation (extensive affection of facial and hairy parts of the head) in patient with chronically active form of ulcerative colitis were complicated with bacterial contamination of methicilin-resistant strains of Staphylococcus aureus. After application of the parenteral feeding, corticotherapy and targeted antibiotic therapy the subjective and objective status of the patient markedly improved, stool frequency was reduced, admixture of blood in the stool disappeared, temperatures fell back and there was a decrease in activity of non-specific bowel inflammation in laboratory findings. However endoscopic examination of the intestine confirmed the finding of chronically active ulcerative colitis with ulcerations and bridging polyps. Patient was indicated to total colectomy, but he refused it.

• MeSH
• dermatózy skalpu patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• obličejové dermatózy patologie   MeSH
• pyoderma gangrenosum komplikace   patologie   MeSH
• ulcerózní kolitida komplikace   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

• Klíčová slova
• COLITIS, ULCERATIVE *, DIAGNOSIS, DIFFERENTIAL *, GANGRENE *, PYODERMA *, SKIN ULCER *, STAPHYLOCOCCAL INFECTIONS *, STREPTOCOCCAL INFECTIONS *,
• MeSH
• diferenciální diagnóza * MeSH
• gangréna * MeSH
• kolitida * MeSH
• kožní vředy * MeSH
• lidé MeSH
• pyodermie * MeSH
• stafylokokové infekce * MeSH
• streptokokové infekce * MeSH
• ulcerózní kolitida * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

An unusual clinical appearance and course of pyoderma gangraenosum (PG) in a 35-year-old woman is presented. Signs of both the ulcerative and vegetative forms of PG were expressed. The association of two systemic diseases, the autoimmune thyreopathy and the hyperandrogenic syndrome were observed in a female. The recommended conventional therapy for PG: corticosteroids, antibiotics, cyclosporine and cyclophosphamide yielded a poor response, whereas after thyroidectomy and reaching an euthyroid state the symptoms receded. This close association of PG and autoimmune thyreopathy supports the autoimmune concept of PG.

• MeSH
• antibakteriální látky terapeutické užití   MeSH
• bakteriální infekce komplikace   farmakoterapie   MeSH
• dospělí MeSH
• Gravesova nemoc komplikace   MeSH
• hyperandrogenismus komplikace   MeSH
• imunosupresiva terapeutické užití   MeSH
• karbimazol terapeutické užití   MeSH
• lidé MeSH
• pyoderma gangrenosum farmakoterapie   etiologie   chirurgie   MeSH
• thyreostatika terapeutické užití   MeSH
• tyreoidektomie MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antibakteriální látky MeSH
• imunosupresiva MeSH
• karbimazol MeSH
• thyreostatika MeSH