Mathematical model of immunological tolerance was applied to polyclonal B cell tolerance induced in mice by treatment with bacterial lipopolysaccharide (LPS) followed by the application of cyclophosphamide (CY). Satisfactory simulation results were obtained with the life-span of lymphocytes shorter than the experimentally observed one. It could be assumed that the massive decrease of lymphocyte population in polyclonal tolerance would elicit a compensatory reaction. Therefore it was postulated that some kind of feedback mechanism increased the influx of B lymphocytes. Having this factor included in the model, satisfactory agreement of the simulation results with experimental data was obtained for experimentally determined life-span of B cells.
- MeSH
- B-Lymphocytes immunology MeSH
- Models, Biological * MeSH
- Time Factors MeSH
- Cyclophosphamide pharmacology MeSH
- Immune Tolerance * MeSH
- Lipopolysaccharides immunology MeSH
- Lymphocyte Depletion MeSH
- Mathematics MeSH
- Mice MeSH
- Serratia marcescens immunology MeSH
- Antibody Formation MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cyclophosphamide MeSH
- Lipopolysaccharides MeSH
