- Keywords
- SCOLIOSIS/experimental *,
- MeSH
- Humans MeSH
- Scoliosis * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Keywords
- MENTAL DISORDERS/statistics *, SCOLIOSIS/statistics *,
- MeSH
- Mental Disorders statistics & numerical data MeSH
- Humans MeSH
- Scoliosis statistics & numerical data MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Keywords
- SCOLIOSIS/epidemiology and statistics *,
- MeSH
- Child MeSH
- Humans MeSH
- Scoliosis epidemiology statistics & numerical data MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
In their work the authors observed the influence of controlled hypotension by means of sodium nitroprusside on the acidobasic balance, the oxygenation parameters, pulmonary shunt and lactatemia in patients with idiopathic scoliosis in the course of dorsal fusion by Harrington instrumentation. In comparison with the control group of patients there had not occurred significant - from the viewpoint of statistics - changes in ph, paCO2 and pvO2. However, the pulmonary shunt (Qva/Qt) doubled (p less than 0.002) which resulted in a significant decrease of paO2 (p less than 0.02) but in no case there occurred hypoxemia. The values of the lactate both in the venous and arterial blood were increased (p less than 0.001, or p less than 0.02) in contrast to the control group of patients, but they did not mean the increased production of lactate during intracellular hypoxia. As a result the regulated hypotension by means of sodium nitroprusside can be applied also in patients with altered pulmonary functions.
- MeSH
- Anesthesia, General * MeSH
- Adult MeSH
- Hypotension, Controlled * MeSH
- Lactates blood MeSH
- Humans MeSH
- Adolescent MeSH
- Pulmonary Circulation * MeSH
- Scoliosis blood physiopathology surgery MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Names of Substances
- Lactates MeSH
BACKGROUND: Adolescent idiopathic scoliosis (AIS) is a common structural spine deformity affecting 2%-4% of adolescents. Due to the unknown cause of idiopathic scoliosis, its therapy is a long-term and often unsatisfactory process. In the literature, it is often suggested that problems related to the feeling of one's own body are caused by AIS. OBJECTIVE: The aim of this study was to assess the feeling of one's own body among children with and without scoliosis on the example of feeling the head position, pelvis shape and balance. METHOD: The research included 62 children: 30 with scoliosis and 25 without diagnosed scoliosis with an age range between 11 to 19 years. The minimum scoliosis value was 7∘ and the maximum was 53∘. The average value was 25∘. During the study, three functional tests were used: Cervical Joint Position Error Test (CJPET), Clinical Test of Sensory Integration on Balance (CTSIB) and Body proportion demonstration test (BPDT). RESULTS: The results of the tests showed statistically significant differences (CJPET p= 3.54*10-14, CTSIB p= 0.0376, BPDT p= 0.0127). However, none of the studies showed a correlation between the results of people with scoliosis and the value of their Cobb angles.
- Keywords
- Scoliosis, body, children, spine deformity, therapy,
- MeSH
- Abdomen physiopathology MeSH
- Sensation physiology MeSH
- Child MeSH
- Physical Examination MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Pelvis physiopathology MeSH
- Spine physiopathology MeSH
- Scoliosis physiopathology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
INTRODUCTION: Fibrinogen is one of the essential coagulation factors. Preoperative lower plasma fibrinogen level has been associated with higher blood loss. Scoliosis surgery presents a challenge for the anaesthetic team, one of the reasons being blood loss and transfusion management. Recently, the prophylactic fibrinogen administration has been a debated topic in various indications. It has been described for example, in urological or cardiovascular surgery, as well as in paediatrics. This pilot study is focused on verifying the feasibility of potential large randomised trial and verifying the safety of prophylactic fibrinogen administration in paediatric scoliosis surgery. METHODS AND ANALYSIS: A total of 32 paediatric patients indicated for scoliosis surgery will be recruited. Participants will be randomised into study groups in a 1:1 allocation ratio. Patients in the intervention group will receive prophylactic single dose of fibrinogen, in addition to standard of care. Patients in the control group will receive standard of care without study medication prior to skin incision. The primary aim is to assess the safety of prophylactic fibrinogen administration during scoliosis surgery in children, the incidence of any adverse events (AEs) and reactions will be monitored during participation in the study. The secondary objective is to investigate the additional safety information, feasibility and efficacy of a prophylactic fibrinogen administration. The incidence of AEs and reactions according to selected adverse events of special interest will be monitored. All collected data will be subjected to statistical analysis according to a separate statistical analysis plan. ETHICS AND DISSEMINATION: This trial follows the applicable legislation and requirements for good clinical practice according to the International Conference on Harmonisation E6(R2). All essential trial documents were approved by the relevant ethics committee and national regulatory authority (State Institute for Drug Control) and their potential amendments will be submitted for approval. TRIAL REGISTRATION NUMBER: NCT05391412.
- Keywords
- anaesthesia in orthopaedics, blood bank & transfusion medicine, orthopaedic & trauma surgery, paediatrics, scoliosis,
- MeSH
- Child MeSH
- Fibrinogen therapeutic use MeSH
- Hemostatics * therapeutic use MeSH
- Hemorrhage prevention & control MeSH
- Humans MeSH
- Pilot Projects MeSH
- Randomized Controlled Trials as Topic MeSH
- Scoliosis * surgery MeSH
- Treatment Outcome MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Clinical Trial Protocol MeSH
- Names of Substances
- Fibrinogen MeSH
- Hemostatics * MeSH
OBJECTS: The exact etiology of scoliosis is still unknown. The main purpose of this study is to search for the possible causation of scoliosis in the development changes of autonomic nervous structures. In this prospective study, we followed-up the changes in peripheral nerve structures and its discrepancies regarding the concavity and convexity of the scoliotic curve. MATERIALS AND METHODS: We evaluated 12 patients with the idiopathic scoliotic deformity and the control group of 3 patients without any scoliotic deformity. The samples from the peripheral nerves of the convexity and concavity of the scoliotic deformity were drawn during the surgical correction by using the transthoracic approach. The samples were examined by the electron microscopic method and morphometric statistical evaluation. RESULTS: In samples taken from the scoliotic convexity, 23.71% of myelinized nerve fibers (MNF), 12.21% of unmyelinized nerve fibers (UNF), and 5.0% of Schwann cells (SC) were found by the morphometric measurement. There were 17.36% of MNF, 5.82% of UNF, and 5.27% of SC in samples taken from the concavity and 29.9% of MNF, 19.9% of UNF, and 16.7% of SC in the control nonscoliotic samples. Statistically significant differences between both sides of scoliotic deformity (convexity and concavity) and differences between the scoliotic samples and the nonscoliotic control samples were found. In all scoliotic samples, significant morphologic changes were found, mostly in the myelin sheaths and axon fiber abnormalities compression. CONCLUSION: There are significant morphologic changes in spinal autonomic nervous structures in scoliotic patients. These findings can help us in the search for the etiology of scoliosis.
- MeSH
- Autonomic Nervous System pathology ultrastructure MeSH
- Humans MeSH
- Prospective Studies MeSH
- Scoliosis etiology pathology MeSH
- Microscopy, Electron, Transmission methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
The authors followed up the impact of a plaster applied in idiopathic scolioses on the pulmonary functions measured by microcomputer spirometer. Pulmonary functions were examined in 24 patients prior to the operation of scoliosis and after the operation in the plaster and in 20 patients treated only by the plaster and on 45th day after its removal. The results of both groups were statistically evaluated by a Student t-test at 1 % level of significance by a personal computer Commodore 16. The results of the examination have shown that the plaster as a therapeutical device in idiopathic scolioses considerably restricts the respiratory functions. Simultaneously there occurs deterioration of the compliance of thoracic wall, a necessary increased activity of the chest and muscles in breathing, alveolar hypoventilation with the retention of CO2. Vital capacity has been reduced by 20 % on the average in operated patients and by 10 % in non-operated idiopathic scolioses in the plaster. In our present conditions, despite the negative impact on respiratory functions by after-treatment of idiopathic scolioses in the plaster, the operation for lengthening of the trunk with the correction of the curvature serves as prevention of the increase of pulmonary insufficiency at the adult age. In the course of two years after operation the respiratory functions start to improve again. Longterm active regime of breathing gymnastics in the patients with idiopathic scoliosis further reduces the negative impact of the plaster on respiratory functions. Key words: idiopathic scoliosis, pulmonary functions, plaster, breathing gymnastics.
- Publication type
- English Abstract MeSH
- Journal Article MeSH
The investigated group comprised 207 patients treated at the spondylologic consulting centre of the orthopaedic clinic where 576 assessment were made with subsequent computer evaluation. Mathematically the correlation between the angle of the costal hunch assessed by a scoliosometer and Cobb's angle on the X-ray picture was calculated. The value of the correlation coefficient was 0.8049. For statistical processing of the results of measurements the authors used the method of robust regression and an equation was calculated according to which the prediced values of Cobb's angle Y were calculated. These results were listed in a table for the extent of measurements from 1 to 16 on the scoliosometer which corresponds to idiopathic scoliosis grade 1 and 2. The scoliosometer is a pendular gravitational instrument which can be replaced by a plummet suspended on a protractor. Assessment of the costal hunch by a scoliosometer can partly reduced check-up examinations of scolioses by X-ray examination of the spine. Key words: scoliosis, scoliosometer, assessment of the costal hunch.
- Publication type
- English Abstract MeSH
- Journal Article MeSH
