In 2006, levels of seven indicator polychlorinated biphenyl congeners (PCB28, 52, 101, 118, 138, 153, and 180) in blood serum of 202 blood donors residing for more than 2 years in five urban areas included in the Czech Human Biomonitoring project were measured by GC/MS/MS method. PCB congeners 138, 153 and 180 accounted for about 97% of the sum of the indicator congeners analyzed. Overall, the median and 95th percentile of the most abundant congener PCB 153 were 438 ng/g lipid and 1079 ng/g lipid, respectively. The highest median levels were found in Uherské Hradiste (669 ng/g lipid) and Ostrava (672 ng/g lipid in males compared to 341 ng/g lipid in females). Serum PCB concentrations were significantly associated with age, gender, place of residence and smoking habit, but not with body mass index and education. The results suggest the importance of PCB body burden in the Czech general population and the existence of hot spots.

• MeSH
• dospělí MeSH
• index tělesné hmotnosti MeSH
• látky znečišťující životní prostředí krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• plynová chromatografie s hmotnostně spektrometrickou detekcí MeSH
• polychlorované bifenyly krev   MeSH
• senioři MeSH
• sexuální faktory MeSH
• věkové faktory MeSH
• vystavení vlivu životního prostředí analýza   MeSH
• zeměpis MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH
• Názvy látek
• 2,2',3',4,4',5-hexachlorobiphenyl MeSH Prohlížeč
• 2,3',4,4',5-pentachlorobiphenyl MeSH Prohlížeč
• 2,4,4'-trichlorobiphenyl MeSH Prohlížeč
• 2,4,5,2',4',5'-hexachlorobiphenyl MeSH Prohlížeč
• 2,4,5,2',5'-pentachlorobiphenyl MeSH Prohlížeč
• 2,5,2',5'-tetrachlorobiphenyl MeSH Prohlížeč
• látky znečišťující životní prostředí MeSH
• PCB 180 MeSH Prohlížeč
• polychlorované bifenyly MeSH

The serum samples from the years 1970-1990 archived at the temperature of -20°C in the biobank primarily intended for serological survey performed in the CR since 1960 were pooled and analyzed for DDT, its metabolites, HCB, HCHs, and indicator PCB congeners using up-to-date GC/MS/MS methods to retrospectively assess health risks according to current health guidelines. Samples were pooled based on the decade of sampling, age, gender, and three geographical areas; in adults, one pooled samples consisted of ten and in children of twenty individual samples. Altogether 233 pooled samples were analyzed. For all organochlorine pesticides (OCPs), significant downward trends were observed in the period 1970-1990 (p<0.001). The levels of HCB exceeded the Biomonitoring Equivalent (BE) value. The hazard quotient (HQ) in Prague and Ostrava during the 1970s and 1980s was about 40 and in the 1990s it had dropped to about five. In Uherské Hradiště, the HQ in 1975 was one order of magnitude higher (about 170), and had decreased to approximately 12 by 1987. For both HCB and the DDT sum, the BE-related carcinogenic risk of actual concentrations in the past exceeded significantly the individually accepted cancer risk level of 10(-4). The levels of the main PCB congeners in the 1970s through 1990s revealed an upward time trend in all analyzed strata. The highest concentrations were found in the serum of residents from the hot-spot area Uherské Hradiště. Critical PCB sum concentration levels (700ng/g lipid for vulnerable population groups and 1800ng/g lipid for other population groups) were substantially exceeded with an increasing time trend. PCB sum had exceeded HBM II values of 7μg/L of serum since 1980 in all age strata. In conclusion, the body burden of the Czech general population relative to persistent organic pollutants (POPs) in the period 1970 through 1990 significantly exceeded currently existing health based limit values. The past exposure might adversely affect the health status of the Czech population.

• Klíčová slova
• Archived serum samples, Czech Republic, Organochlorine pesticides, Polychlorinated biphenyls, Risk assessment,
• MeSH
• chlorované uhlovodíky krev   MeSH
• dítě MeSH
• dospělí MeSH
• hodnocení rizik MeSH
• kojenec MeSH
• látky znečišťující životní prostředí krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• monitorování životního prostředí statistika a číselné údaje   MeSH
• novorozenec MeSH
• pesticidy krev   MeSH
• předškolní dítě MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• kojenec MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• novorozenec MeSH
• předškolní dítě MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH
• Názvy látek
• chlorované uhlovodíky MeSH
• látky znečišťující životní prostředí MeSH
• pesticidy MeSH